| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Bioengineering Institute, University of Auckland, Auckland, New Zealand
2 Department of Radiology, University of Iowa, Iowa City, Iowa, USA
3 Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa, USA
4 Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa, USA; Department of Medicine, University of Iowa, Iowa City, Iowa, USA
5 Department of Radiology, University of Iowa, Iowa City, Iowa, USA; Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa, USA
* To whom correspondence should be addressed. E-mail: m.tawhai{at}auckland.ac.nz.
The interpretation of experimental results from functional medical imaging is complicated by inter-subject and inter-species differences in airway geometry. The application of computational models in understanding the significance of these differences requires methods for generation of subject-specific geometric models of the bronchial airway tree. In the current study curvilinear airway centerline and diameter models have been fitted to human and ovine bronchial trees using detailed data segmented from multidetector row x-ray computed tomography scans. The trees have been extended to model the entire conducting airway system, by using a volume-filling algorithm to generate airway centerline locations within detailed volume descriptions of the lungs or lobes. Analysis of the geometry of the scan-based and model-based airways has verified their consistency with measures from previous anatomical studies, and has provided new anatomical data for the ovine bronchial tree. Using an identical parameter set, the volume-filling algorithm has produced airway trees with branching asymmetry appropriate for the human and ovine lung, demonstrating the dependence of the method on the shape of the lung or lobe volume. The modeling approach that has been developed can be applied to any level of detail of the airway tree and into any volume shape for the lung, hence it can be used directly for different individuals or animals, and for any number of scan-based airways. The resulting models are subject-specific computational meshes with anatomically-consistent geometry, suitable for application in simulation studies.
This article has been cited by other articles:
|
|
 |
|
  M. H. Tawhai, M. P. Nash, C.-L. Lin, and E. A. Hoffman Supine and prone differences in regional lung density and pleural pressure gradients in the human lung with constant shape J Appl Physiol, September 1, 2009; 107(3): 912 - 920. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.S Burrowes, A.J Swan, N.J Warren, and M.H Tawhai Towards a virtual lung: multi-scale, multi-physics modelling of the pulmonary system Phil Trans R Soc A, September 28, 2008; 366(1879): 3247 - 3263. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Tsuda, N. Filipovic, D. Haberthur, R. Dickie, Y. Matsui, M. Stampanoni, and J. C. Schittny Finite element 3D reconstruction of the pulmonary acinus imaged by synchrotron X-ray tomography J Appl Physiol, September 1, 2008; 105(3): 964 - 976. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. T. Tgavalekos, G. Musch, R. S. Harris, M. F. Vidal Melo, T. Winkler, T. Schroeder, R. Callahan, K. R. Lutchen, and J. G. Venegas Relationship between airway narrowing, patchy ventilation and lung mechanics in asthmatics Eur. Respir. J., June 1, 2007; 29(6): 1174 - 1181. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. de Rochefort, L. Vial, R. Fodil, X. Maitre, B. Louis, D. Isabey, G. Caillibotte, M. Thiriet, J. Bittoun, E. Durand, et al. In vitro validation of computational fluid dynamic simulation in human proximal airways with hyperpolarized 3He magnetic resonance phase-contrast velocimetry J Appl Physiol, May 1, 2007; 102(5): 2012 - 2023. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. H. Tawhai, K. S. Burrowes, and E. A. Hoffman Computational models of structure-function relationships in the pulmonary circulation and their validation Exp Physiol, March 1, 2006; 91(2): 285 - 293. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. A. Simon, G. E. Christensen, D. A. Low, and J. M. Reinhardt Computed Tomography Studies of Lung Mechanics Proceedings of the ATS, December 1, 2005; 2(6): 517 - 521. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. T. Tgavalekos, M. Tawhai, R. S. Harris, G. Mush, M. Vidal-Melo, J. G. Venegas, and K. R. Lutchen Identifying airways responsible for heterogeneous ventilation and mechanical dysfunction in asthma: an image functional modeling approach J Appl Physiol, December 1, 2005; 99(6): 2388 - 2397. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Hunter and P. Nielsen A Strategy for Integrative Computational Physiology Physiology, October 1, 2005; 20(5): 316 - 325. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. S. Burrowes, P. J. Hunter, and M. H. Tawhai Anatomically based finite element models of the human pulmonary arterial and venous trees including supernumerary vessels J Appl Physiol, August 1, 2005; 99(2): 731 - 738. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
