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J Appl Physiol (September 27, 2002). doi:10.1152/japplphysiol.00513.2002
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Articles in PresS, published online ahead of print September 27, 2002
J Appl Physiol, 10.1152/jap.00513.2002
Submitted on June 12, 2002
Accepted on September 26, 2002

In Vivo Rabbit Hindquarter Model for Assessment of Regional Burn Hypermetabolism

Ji Xu1, Zhewei Fei1, Yong-Ming Yu1, Wenyin Xu1, Andrew Rhodes1, Ronald G Tompkins1, and John T Schulz1*

1 Research, Shriners Burns Hospital, Boston, MA, USA; Surgery, Massachusetts General Hospital, Boston, MA, USA

* To whom correspondence should be addressed. E-mail: jschulz{at}partners.org.

Severe burn injury evokes hypermetabolism and muscle wasting, despite nominally adequate nutrition. Although there is much data on whole organism and isolated tissue metabolism following burn injury, data examining regional burn hypermetabolism in vivo is lacking. Using surgically implanted (general anesthesia) regional vascular catheters and primed constant infusion of L-[1-13C]phenylalanine tracer, we have determined in vivo burn-induced alterations in rabbit hindquarter protein and energy metabolism. Burn injury evokes increased whole body resting energy expenditure and phenylalanine turnover, accompanied by significantly increased hindquarter proteolysis, creating a negative protein balance in burned rabbit hindquarter. Hindquarter oxygen consumption increased after burn injury, but the increment did not reach statistical significance. Burn-induced changes in hindlimb protein turnover account for approximately one third of the whole animal hypermetabolism. This model offers a system for regional manipulation of post-burn hypermetabolism.




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