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Articles in PresS, published online ahead of print August 23, 2002
J Appl Physiol, 10.1152/jap.00511.2002
Submitted on June 12, 2002
Accepted on August 22, 2002
1 Health Sciences, Humboldt State University, Arcata, California, USA
2 College of Health and Human Performance, Center for Exercise Science, University of Florida, Gainesville, Florida, USA
* To whom correspondence should be addressed. E-mail: sdodd{at}hhp.ufl.edu.
Previous studies have increased antioxidant capacity in skeletal muscle in order to attenuate oxidative stress and muscle atrophy during limb immobilization. The purpose of this study was to determine the level of oxidative stress in muscle during hindlimb unweighting (HLU) and, if antioxidant supplementation can attenuate the atrophy and changes in contractile properties resulting from 14 days of unweighting. Muscle unweighting caused a 44% decrease in soleus (SOL) and a 30% decrease in gastrocnemius (GS) mass, a 7% decrease in body weight, and 28% decrease in tetanic force in the GS. Protein carbonyls increased 44% in the SOL with HLU. Antioxidant supplementation did not attenuate the GS or SOL atrophy or the decrease in GS force generation during HLU. SOL and GS protein concentration was not different between groups. The GS was also subjected to three different oxidative challenges in order to determine if the supplement increased the antioxidant capacity of the muscle. In all cases, muscles exhibited an increased antioxidant capacity. These data indicate that antioxidant supplementation was not an effective countermeasure to the atrophy associated with HLU.
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