| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Department of Respiratory Medicine and the National Referral Centre for Adult Cystic Fibrosis, St. Vincent's University Hospital, Ireland
* To whom correspondence should be addressed. E-mail: v.hearn{at}st-vincents.ie.
Background: Patients with Cystic Fibrosis (CF) have reduced peripheral muscle strength. We tested the hypothesis that steroid treatment contributes to muscle weakness in adults with CF. Methods: 23 stable CF patients were studied. Measurements included knee extensor (KE), knee flexor (KF), elbow flexor (EF), handgrip (HG), expiratory (Pemax) and inspiratory (Pimax) muscle strengths. Spirometry, body mass index (BMI) and days spent in hospital over the preceding 12 months (DH) were also measured. Average daily dose of prednisolone over the preceding 12 months (ADD) was 5.1mg per day. Results: Pearson's correlation analysis revealed that ADD correlated significantly with skeletal muscle strengths (KF%, r=-0.63, p<0.01) with the exception of HG%. These findings are independent of age, BMI, pulmonary function and DH. Multiple regression analysis revealed that, ADD was the most significant predictor of all measures of skeletal muscle function except HG%. It was independently responsible for 54% of the variance in Pimax%, for 46% of the variance in Pemax%, for 45% of the variance in KE%, for 39% of the variance in KF% and for 41% of the variance in EF%. Concomitant medications (e.g. theophylline) were shown to have no causative effect. Conclusion: Corticosteroids contribute to the skeletal muscle weakness seen in CF patients. The correlation of proximal muscle strength, but not handgrip strength, with steroid dosage further supports a cause-effect relationship.
This article has been cited by other articles:
|
|
 |
|
  T. Troosters, D. Langer, B. Vrijsen, J. Segers, K. Wouters, W. Janssens, R. Gosselink, M. Decramer, and L. Dupont Skeletal muscle weakness, exercise tolerance and physical activity in adults with cystic fibrosis Eur. Respir. J., January 1, 2009; 33(1): 99 - 106. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Barry, D. F. Waterhouse, C. M. Reilly, T. J. McKenna, E. F. McKone, and C. G. Gallagher Androgens, Exercise Capacity, and Muscle Function in Cystic Fibrosis Chest, December 1, 2008; 134(6): 1258 - 1264. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O Schakman, H Gilson, and J P Thissen Mechanisms of glucocorticoid-induced myopathy J. Endocrinol., April 1, 2008; 197(1): 1 - 10. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Sahlberg, U. Svantesson, E. M. L. M. Thomas, and B. Strandvik Muscular Strength and Function in Patients With Cystic Fibrosis Chest, May 1, 2005; 127(5): 1587 - 1592. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M A Spruit, M J Thomeer, R Gosselink, T Troosters, A Kasran, A J T Debrock, M G Demedts, and M Decramer Skeletal muscle weakness in patients with sarcoidosis and its relationship with exercise intolerance and reduced health status Thorax, January 1, 2005; 60(1): 32 - 38. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C Pinet, P Scillia, M Cassart, M Lamotte, C Knoop, C Melot, and M Estenne Preferential reduction of quadriceps over respiratory muscle strength and bulk after lung transplantation for cystic fibrosis Thorax, September 1, 2004; 59(9): 783 - 789. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
