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1 Department of Physiology, Australian Institute of Sport, Canberra, ACT, Australia
2 Health Science / Sport and Recreation, Auckland University of Technology, Auckland, New Zealand
3 Royal Brisbane and Womens Hospital, Brisbane, QLD, Australia
* To whom correspondence should be addressed. E-mail: chris.gore{at}ausport.gov.au.
The volume of red blood cells (VRBC) is used routinely in the diagnostic work-up of polycythemia, in assessing the efficacy of erythropoietin administration, and to study factors affecting oxygen transport. However, errors of various methods of measurement of VRBC and related parameters are not well characterized. We meta-analyzed 346 estimates of error of measurement of VRBC for techniques based on Evans blue (VRBC, Evans), 51chromium-labelled red cells (VRBC, 51Cr) and carbon-monoxide rebreathing (VRBC, CO), as well as hemoglobin mass with the carbon-monoxide method (MHb, CO), in athletes, active and inactive subjects undergoing various experimental and control treatments lasting minutes to months. Subject characteristics and experimental treatments had little effect on error of measurement, but measures with the smallest error showed some increase in error with increasing time between trials. Adjusted to 1-day between trials and expressed as coefficients of variation, mean errors for MHb, CO (2.2%; 90% confidence interval 1.4-3.5%) and VRBC, 51Cr (2.8%; 2.4-3.2%) were much less than those for VRBC, Evans (6.7%; 4.9-9.4%) and VRBC, CO (6.7%; 3.4-14%). Most of the error of VRBC, Evans was due to error in measurement of VPlasma, Evans (6.0%; 4.5-7.8%), which is the basis of VRBC, Evans. Most of the error in VRBC, CO was due to estimates from laboratories with a relatively large error in MHb CO, the basis of VRBC, CO. VRBC, 51Cr and MHb, CO are the best measures for research on blood-related changes in oxygen transport. With care, VRBC, Evans is suitable for clinical applications of blood-volume measurement.
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