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1 Molecular Biology Program, New Mexico State University, Las Cruces, NM, USA
2 Department Ecology, Evolution, and Behavior, University of Minnesota, St. Paul, MN, USA
* To whom correspondence should be addressed. E-mail: wvanvoor{at}nmsu.edu.
In a recent study examining the relationship between longevity and metabolism in a large number of recombinant inbred (RI) Drosophila melanogaster lines, we found no indication of the inverse relationship between longevity and metabolic rate that one would expect under the classical "rate of living" model. A potential limitation in generalizing from that study is that it was conducted on experimental material derived from a single set of parental strains originally developed over 20 years ago. In order to determine whether the observations made with those lines are characteristic of the species, we studied metabolic rates and longevities in a second, independently derived set of RI lines. We found no correlation in these lines between metabolic rate and longevity, indicating that the ability to both maintain a normal metabolic rate and have extended longevity may apply to D. melanogaster in general. In order to determine how closely our measurements reflect metabolic rates of flies maintained under conditions of life span assays, we used long-term, flow-through metabolic rate measurements and closed system respirometery to examine the effects of variables such as time of day, feeding state, fly density, feeding state, mobility of the flies, and nitrogen knock-out on D. melanogaster metabolic rate. We found that CO2 production estimated in individual flies accurately reflects metabolic rates of flies under the conditions used for longevity assays.
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