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J Appl Physiol (August 30, 2002). doi:10.1152/japplphysiol.00492.2002
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Articles in PresS, published online ahead of print August 30, 2002
J Appl Physiol, 10.1152/jap.00492.2002
Submitted on June 5, 2002
Accepted on August 26, 2002

Effect of gravity and posture on lung mechanics

Dario Bettinelli1, Christian Kays2, Olivier Bailliart3, Andre Capderou4, Pierre Techoueyres2, Jean-Luc Lachaud2, Pierre Vaida2, and Giuseppe Miserocchi1*

1 Dept. of Experimental and Environmental Medicine, University of Milan-Bicocca, Monza, Milan, Italy
2 Dept. of Space Medicine, University of Bordeaux 2, Bordeaux, France
3 Lariboisière Hospital, Paris, France
4 CCML, University of Paris, Paris, France

* To whom correspondence should be addressed. E-mail: giuseppe.miserocchi{at}unimib.it.

The volume pressure relationship of the lung was studied in six subjects on changing the gravity vector during parabolic flights and body posture. Lung recoil pressure decreased by about 2.7 cmH2O going from 1 to 0Gz while it increased by about 3.5 cmH2O in 30° tilted head-up and supine posture. No substantial change was found going from 1 to 1.8 Gz. Matching the changes in volume-pressure relationships of the lung and chest wall (previous data), results in a decrease in functional respiratory capacity (FRC) of about 580 ml at 0Gz relative to 1Gz, and of about 1200 ml going to supine posture. Microgravity causes a decrease in lung and chest wall recoil pressures as it removes most of the distortion of lung parenchyma and thorax induced by changing gravity field/posture. Hypergravity does not greatly affect respiratory mechanics suggesting that mechanical distorsion is close to maximum already at 1 Gz. The end-expiratory volume during quite breathing corresponds to the mechanical FRC in each condition.




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