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1 Department of Medicine, and Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina, School of Medicine, Chapel Hill, NC, USA
2 National Center for Environment Assessment, US Environmental Protectin Agency, Research Triangle Park, NC, USA
* To whom correspondence should be addressed. E-mail: mhazucha{at}med.unc.edu.
Subjects were healthy non-smoking men (n=146) and women (n=94) 18-60 yrs old. Initially, each subject was exposed for 1.5 hr to 0.42 ppm O3. Forty seven individuals were later re-exposed twice, one week to several months apart, to 0.4 ppm O3. Intermittent exercise utilized in all exposures was adjusted to produce an ozone dose of 560 ppm x L/m2 BSA. The post-O3 
%FEV1 decrements of young (18-35 yrs) and middle-age (36-60 yrs) males and females differed significantly (p<0.05) from normal distribution with values skewed towards larger decrements in younger subjects. The respective mean %FEV1 were -16.3%, -16.6%, -11.6%, and -6.4%. The rate of decline with age was 3.5 times higher in young females as compared with young males (p<0.05). This pattern was reversed in the middle-age cohort. Our data support earlier reports of no significant difference in spirometric response to O3 between young men and women. The data also confirm that large FEV1 decrements following O3 exposure are mostly confined to younger individuals that also show much greater variance in response to repeated exposures than the middle-age subjects. The majority of subjects remained in their initial category of O3 sensitivity on retesting after various time lapses. The r value (Spearman) between the 1st and 2nd, and 1st and 3rd exposure response ranged from 0.544 to 0.850, depending on classification. However, the mean %FEV1 differed by as much as 6 percentage points between exposure days. The yearly loss of responsiveness (0.2% to 0.7%/year) with progressing age determined by cross-sectional analyses was substantially smaller.
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