Journal of Applied Physiology Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

J Appl Physiol (July 11, 2003). doi:10.1152/japplphysiol.00486.2003
This Article
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
95/5/1883    most recent
00486.2003v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pliquett, R. U
Right arrow Articles by Zucker, I. H
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pliquett, R. U
Right arrow Articles by Zucker, I. H
Submitted on May 8, 2003
Accepted on July 10, 2003

Amelioration of Depressed Cardiopulmonary Reflex Control of Sympathetic Nerve Activity by Short-Term Exercise Training in Male Rabbits with Heart Failure

Rainer U Pliquett1, Kurtis G Cornish1, Kaushik P Patel1, Harold D Schultz1, Jacob D Peuler2, and Irving H Zucker1*

1 Department of Physiology and Biophysics, University of Nebraska Medical Center, Omaha, NE, USA
2 Department of Pharmacology, Midwestern University, Downers Grove, IL, USA

* To whom correspondence should be addressed. E-mail: izucker{at}unmc.edu.

The reflex regulation of sympathetic nerve activity has been demonstrated to be impaired in the chronic heart failure (CHF) state compared to the normal condition. Exercise training (EX) appears to be beneficial to patients with CHF and has been shown to reduce sympathetic outflow in this disease state. We tested the hypothesis that EX corrects the reduced cardiopulmonary (CP) reflex response to volume expansion in the CHF state. Normal, Normal+EX, CHF, CHF+EX-groups (n=10-21) of male New Zealand White rabbits were studied. CHF was induced by chronic ventricular pacing. Rabbits were instrumented to record left ventricular end diastolic pressure (LVEDP), - diameter (LVEDD) and renal sympathetic nerve activity (RSNA). Experiments were carried out in the conscious state. Volume expansion was performed with 6% dextran in normal saline at a rate of 5 ml/min to approximately 20% of estimated plasma volume without exhibiting any significant effect on mean arterial pressure. The relationships between RSNA-LVEDP and RSNA-LVEDD were determined by linear regression, the slopes served as an index of CP reflex sensitivity. Normal rabbits exhibited a CP reflex sensitivity of -8.4±1.5 %{Delta} RSNA/mm Hg. This value fell to 0.0±1.3 %{Delta} RSNA/mm Hg in CHF rabbits (p<0.001). EX increased CP reflex sensitivity to -5.0±0.7 %{Delta} RSNA/mm Hg in CHF-EX rabbits (p<0.05 compared to CHF). A similar trend was seen when related to the change in LVEDD. Furthermore, resting RSNA expressed as a % of maximum RSNA in response to cigarette smoke was also normalized by EX in rabbits with CHF. EX had no effect on these parameters in normal rabbits. These data confirm an impairment of CP-reflex sensitivity and sympatho-excitation in CHF versus normal animals. EX substantially restored both CP-reflex sensitivity and baseline RSNA in CH-animals. Thus, EX beneficially affects reflex regulation in CHF, thereby lowering resting sympathetic nerve activity.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
I. H. Zucker, H. D. Schultz, K. P. Patel, W. Wang, and L. Gao
Regulation of central angiotensin type 1 receptors and sympathetic outflow in heart failure
Am J Physiol Heart Circ Physiol, November 1, 2009; 297(5): H1557 - H1566.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. C. Kleiber, H. Zheng, H. D. Schultz, J. D. Peuler, and K. P. Patel
Exercise training normalizes enhanced glutamate-mediated sympathetic activation from the PVN in heart failure
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2008; 294(6): R1863 - R1872.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
X. Xu, W. Wan, L. Ji, S. Lao, A. S. Powers, W. Zhao, J. M. Erikson, and J. Q. Zhang
Exercise training combined with angiotensin II receptor blockade limits post-infarct ventricular remodelling in rats
Cardiovasc Res, June 1, 2008; 78(3): 523 - 532.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
L. Gao, W. Wang, D. Liu, and I. H. Zucker
Exercise Training Normalizes Sympathetic Outflow by Central Antioxidant Mechanisms in Rabbits With Pacing-Induced Chronic Heart Failure
Circulation, June 19, 2007; 115(24): 3095 - 3102.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Heart FailHome page
R. Fraga, F. G. Franco, F. Roveda, L. N.J. de Matos, A. M.F.W. Braga, M. U.P.B. Rondon, D. R. Rotta, P. C. Brum, A. C.P. Barretto, H. R. Middlekauff, et al.
Exercise training reduces sympathetic nerve activity in heart failure patients treated with carvedilol
Eur J Heart Fail, June 1, 2007; 9(6-7): 630 - 636.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
H. Zheng, Y.-F. Li, I. H. Zucker, and K. P. Patel
Exercise training improves renal excretory responses to acute volume expansion in rats with heart failure
Am J Physiol Renal Physiol, December 1, 2006; 291(6): F1148 - F1156.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1966 by the American Physiological Society.