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Articles in PresS, published online ahead of print July 12, 2002
J Appl Physiol, 10.1152/jap.00473.2002
Submitted on May 28, 2002
Accepted on June 24, 2002
1 Department of Medicine, University of Vermont, Burlington, VT, USA
2 Department of Medicine, University of Vermont, Burlington, VT, USA; Department of Clinical Physiology, University of Lund, Malmo, Sweden
* To whom correspondence should be addressed. E-mail: gballen{at}zoo.uvm.edu.
The lasting effects of a recruitment maneuver (RM) in the injured lung are not well characterized. We speculated that the reduction in respiratory elastance (H) following a deep inflation (DI) is transient in nature, and should be sustained longer at higher positive end-expiratory pressure (PEEP). Thirteen ventilated mice were given 2 DI's at various levels of PEEP, before and after saline lavage. Forced-oscillations were used to measure respiratory elastance (H) periodically over 7 min following the DIs. Time constants (
) were estimated for the post-DI recovery in H. Values for before lavage (80 to 115 s) were reduced following lavage (13 to 30 s) at all levels of PEEP (p=0.0001). PEEP did not significantly influence before or after lavage. The plateau level and total recovery in H following a DI were significantly influenced by PEEP and lavage (p<0.0001). Our results suggest that for a DI to be beneficial in the injured mouse lung, it may have to be applied several times a minute.
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