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J Appl Physiol (December 7, 2001). doi:10.1152/japplphysiol.00465.2001
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Articles in PresS, published online ahead of print December 7, 2001
J Appl Physiol, 10.1152/jap.00465.2001
Submitted on May 10, 2001
Accepted on November 23, 2001

Plasma corticosterone response to acute and chronic voluntary exercise in female house mice

Isabelle Girard1* and Theodore, Jr. Garland2

1 Zoology, University of Wisconsin, Madison, WI, USA
2 Biology, University of California Riverside, Riverside, CA, USA

* To whom correspondence should be addressed. E-mail: igirard{at}facstaff.wisc.edu.

Plasma levels of corticosterone (B) respond acutely to exercise in all mammals that have been studied, but the literature contains conflicting reports regarding how chronic activity alters this response. We measured acute and chronic effects of voluntary activity on B levels in a novel animal model, mice selectively bred for high voluntary wheel running. Female mice were housed with or without wheels for 8 weeks beginning at 26 days of age. Wheel-access selection mice had significantly higher B at Night 8, Day 15, and Night 29, as compared with wheel-access controls. Elevation of B was an acute effect of voluntary exercise: when adjusted for running in previous 20 minutes, no difference between wheel-access selection and control animals remained. No training effect on corticosterone response was observed. These results are among the strongest evidence that, in some animals, the acute B response is unaffected by chronic voluntary exercise. In mice without wheels, selection mice had significantly higher B levels than controls at Day 15, Night 29, and Night 50, suggesting that selection has resulted in a modulation of the HPA axis. Growth over the first four weeks of treatment was significantly inversely related to average night corticosterone levels within each of the four treatment groups.




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