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Articles in PresS, published online ahead of print August 30, 2002
J Appl Physiol, 10.1152/jap.00446.2002
Submitted on May 20, 2002
Accepted on August 27, 2002
1 Department of Physiology, St. George's Hospital Medical School, London, United Kingdom; Department of Medicine, Division of Physiology, University of California, San Diego, San Diego, CA, USA
2 Centre for Exercise Science and Medicine, University of Glasgow, Glasgow, United Kingdom
3 Department of Biochemistry, St. George's Hospital Medical School, London, United Kingdom
4 Center for Activity and Ageing, School of Kinesiology and Department of Physiology, University of Western Ontario, London, Ontario, Canada
5 Department of Physiology, St. George's Hospital Medical School, London, United Kingdom; Centre for Exercise Science and Medicine, University of Glasgow, Glasgow, United Kingdom
* To whom correspondence should be addressed. E-mail: bwhipp{at}rei.edu.
The dynamics of pulmonary O2 uptake (VO2) during the on-transient of high-intensity exercise depart from mono-exponentiality as a result of a "slow-component" whose mechanisms remain conjectural. Progressive recruitment of glycolytic muscle fibres, with slow O2 utilisation kinetics and low efficiency has, however, been suggested as a mechanism. The demonstration of high- and low-pH components of the exercising skeletal muscle 31P MR spectrum (inorganic phosphate (Pi) peak) at high work rates (thought to be reflective of differences between oxidative and glycolytic muscle fibers), is also consistent with this conjecture. We therefore investigated the dynamics of VO2 (using a turbine and mass spectrometry) and intramuscular [ATP], [PCr], [Pi] and pH - estimated from the 31P MR spectrum. Eleven healthy males performed prone square-wave high-intensity knee-extensor exercise in the bore of a whole-body MR spectrometer. A VO2 slow component of magnitude 15.9% (±6.9, SD) of the phase II amplitude was accompanied by a similar response (11.9%, ±7.1) in [PCr]. Only 5 subjects demonstrated a discernible splitting of the Pi peak, however, which began from between 35 to 235 s after exercise onset, and continued to cessation. As such, the dynamics of the pH distribution in intramuscular compartments did not consistently reflect the temporal features of the VO2 slow component, suggesting that [Pi] splitting does not uniquely reflect the activity of oxidative or glycolytic muscle fibres per se.
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