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Articles in PresS, published online ahead of print September 6, 2002
J Appl Physiol, 10.1152/jap.00443.2002
Submitted on May 17, 2002
Accepted on August 30, 2002
1 Medicine, Division of Cardiology, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, PA, USA
2 Medicine, Division of Cardiology, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, PA, USA; Lebanon Veterans Affairs Medical Center, Lebanon, PA, USA
* To whom correspondence should be addressed. E-mail: lsinoway{at}psu.edu.
The effects of changes in transmural pressure on brachial artery mean blood velocity (MBV) were examined in humans. Transmural pressure was altered using a specially designed pressure tank that raised or lowered forearm pressure by 50 mmHg within 0.2 s. Brachial MBV was measured with Doppler directly above the site of forearm pressure change. Pressure changes were evoked during resting conditions and following a 5 s handgrip contraction at 25% maximal voluntary contraction. The handgrip protocol selected was sufficiently vigorous to limit flow and sufficiently brief to prevent autonomic engagement. Changes in transmural pressure evoked directionally similar changes in MBV within 2 s. This was followed by large and rapid adjustments (-2.14 ± .24 cm/s [vasoconstriction] during negative pressure and +2.14 ± .45 cm/s [vasodilatation] during positive pressure). These adjustments served to return MBV to resting levels. This regulatory influence remained operative after 5 s static handgrip contractions. Of note, changes in transmural pressure were capable of altering the timing of the peak MBV response (5 ± 0, 2 ± 0, 6 ± 1 s; ambient, negative and positive pressure, respectively) as well as the speed of MBV adjustment (-2.03 ± .18; -2.48 ± .15; -.84 ± .19 cm/s/s; ambient, negative and positive pressure, respectively) following handgrip contractions. The vascular responses, seen with changes in transmural pressure, provides evidence that the myogenic response is normally operative in the limb circulation of humans.
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