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J Appl Physiol (July 25, 2003). doi:10.1152/japplphysiol.00441.2003
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Submitted on May 1, 2003
Accepted on July 21, 2003

Left ventricular diastolic filling and systolic function of young and older trained and untrained men

James C Baldi1*, Kendra McFarlane1, Helen C Oxenham2, Gillian A Whalley2, Helen J Walsh2, and Robert N Doughty2

1 Department of Sport and Exercise Science, The University of Auckland, Auckland, New Zealand
2 Department of Cardiovascular Research, School of Medicine, The University of Auckland, Auckland, New Zealand

* To whom correspondence should be addressed. E-mail: j.baldi{at}auckland.ac.nz.

Aging is associated with impaired early diastolic filling; however the effect of endurance training on resting diastolic function in older subjects is unclear. Heart rate and ventricular loading conditions affect mitral inflow velocities measured by Doppler echocardiography, therefore tissue Doppler imaging of mitral annular velocity, which is relatively pre-load independent, was combined with mitral inflow velocity and maximal oxygen consumption (VO2max) in young (20 to 35 yrs.) and older (60 to 80 yrs.) trained and untrained men to determine whether endurance training is associated with an attenuation of age-associated changes in diastolic filling. As expected, VO2max was higher in trained men (p < 0.01) and lower in older men (p < 0.01). Peak early mitral inflow velocity (E) and early to late inflow velocity ratios, (E/A) were lower in older vs. young men (p < 0.01), however there was no training effect (p > 0.05). Peak early mitral annular velocity (E') was higher and peak late mitral annular velocity (A') was lower in young vs. older men (p < 0.01). A significant interaction effect was found for A', E'/A' and peak systolic mitral annular velocity (S'). Training was associated with lower A' in young and higher A' in older men. S' was greater in trained vs. untrained older men (p < 0.05), but was similar in trained and untrained young men. These findings suggest that early diastolic filling is not affected by training in older men and the effect of training on A' and S' is different in young and older men.




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