Journal of Applied Physiology AJP: Renal Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

J Appl Physiol (October 18, 2002). doi:10.1152/japplphysiol.00441.2002
This Article
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
94/2/612    most recent
00441.2002v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zhu, X.
Right arrow Articles by Dekhuijzen, P. N. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zhu, X.
Right arrow Articles by Dekhuijzen, P. N. R.

Articles in PresS, published online ahead of print October 18, 2002
J Appl Physiol, 10.1152/jap.00441.2002
Submitted on May 17, 2002
Accepted on October 9, 2002

EFFECTS OF MODULATION OF NITRIC OXIDE ON RAT DIAPHRAGM ISOTONIC CONTRACTILITY DURING HYPOXIA

XiaoPing Zhu1, Leo M. A. Heunks2, Herwin A. Machiels2, Leo Ennen2, and P. N. Richard Dekhuijzen2*

1 Department of Pulmonary Diseases, University Medical Centre Nijmegen, Nijmegen, The Netherlands; Department of Pulmonary Diseases, NingXia Medical College Hospital, Yinchuan, NingXia, China
2 Department of Pulmonary Diseases, University Medical Centre Nijmegen, Nijmegen, The Netherlands

* To whom correspondence should be addressed. E-mail: r.dekhuijzen{at}long.azn.nl.

Nitric oxide (NO) is essential for optimal myofilament function of the rat diaphragm in vitro during active shortening. Little is known about the role of NO in muscle contraction under hypoxic conditions. Hypoxia might increase the NO synthase (NOS) activity within the rat diaphragm. We hypothesized that NO plays a protective role in isotonic contractile and fatigue properties during hypoxia in vitro. The effects of the NOS inhibitor NG-Monomethyl-L-arginine (L-NMMA), the NO scavenger hemoglobin and the NO donor Spermine NONOate (Sp-NO) on shortening velocity, power generation and isotonic fatigability during hypoxia were evaluated (pO2 ~ 7 kPa). L-NMMA and hemoglobin slowed the shortening velocity, depressed power generation and increased isotonic fatigability during hypoxia. The effects of L-NMMA were prevented by co-administration with the NOS substrate L-arginine. Sp-NO did not alter isotonic contractile and fatigue properties during hypoxia. These results indicate that endogenous NO is needed for optimal muscle contraction of the rat diaphragm in vitro during hypoxia.




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
L. F. Ferreira and M. B. Reid
Muscle-derived ROS and thiol regulation in muscle fatigue
J Appl Physiol, March 1, 2008; 104(3): 853 - 860.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
C. A. C. Ottenheijm, L. M. A. Heunks, M. C. P. Geraedts, and P. N. R. Dekhuijzen
Hypoxia-induced skeletal muscle fiber dysfunction: role for reactive nitrogen species
Am J Physiol Lung Cell Mol Physiol, January 1, 2006; 290(1): L127 - L135.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
X. Zhu, L. M. A. Heunks, E. M. M. Versteeg, H. F. M. van der Heijden, L. Ennen, T. H. van Kuppevelt, J. Vina, and P. N. R. Dekhuijzen
Hypoxia-induced dysfunction of rat diaphragm: role of peroxynitrite
Am J Physiol Lung Cell Mol Physiol, January 1, 2005; 288(1): L16 - L26.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1966 by the American Physiological Society.