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J Appl Physiol (May 26, 2005). doi:10.1152/japplphysiol.00435.2005
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Submitted on April 18, 2005
Accepted on May 24, 2005

Acute dopamine/noradrenaline reuptake inhibition increases brain and core temperature in rats

Hiroshi Hasegawa1, Romain Meeusen2*, Sophie Sarre3, Marc Diltoer3, Maria Francesca Piacentini4, and Yvette Michotte3

1 Department of Human Physiology and Sportsmedicine, Vrije Universiteit Brussel, Brussels, Belgium; Department of Pharmaceutical Chemistry and Drug Analysis, Vrije Universiteit Brussel, Brussels, Belgium; Integrated Arts and Sciences, Hiroshima University, Higashihiroshima, Japan
2 Department of Human Physiology and Sportsmedicine, Vrije Universiteit Brussel, Brussels, Belgium
3 Department of Pharmaceutical Chemistry and Drug Analysis, Vrije Universiteit Brussel, Brussels, Belgium
4 Department of Human Physiology and Sportsmedicine, Vrije Universiteit Brussel, Brussels, Belgium; Department of Human Movement and Sport Sciences, Istituto Universitario di Scienze Motorie, Rome, Italy

* To whom correspondence should be addressed. E-mail: rmeeusen{at}vub.ac.be.

The purpose of the present study was to examine the effects of an acute dose of the dual dopamine (DA) noradrenaline (NA) reuptake inhibitor bupropion (BUP) on brain, core and tail skin temperature in freely moving rats, and to simultaneously monitor the extracellular neurotransmitter concentrations in the preoptic area and anterior hypothalamus (PO/AH). A microdialysis probe was inserted in the PO/AH, and samples for NA, DA and serotonin (5-HT) were collected every 20 min prior to and after the injection of 17 mg/kg of BUP, for a total sampling time of 180 min. Body core temperature (Tcore) was monitored using a biotelemetry system. Brain (Tbrain) and tail skin temperature (Ttail), an index of heat loss response, were also measured. Both NA and DA levels in the PO/AH significantly increased after BUP injection compared with the baseline levels reaching about 450% and 230% respectively 40 min after injection. There was no effect on 5-HT release. The neurotransmitter changes were accompanied by a significant decrease in Ttail and an increase in both Tbrain and Tcore compared with the baseline levels. The present results demonstrate that inhibition of NA and DA reuptake suppresses heat loss mechanisms and elevates brain and core temperatures in freely moving rats.




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H. Hasegawa, M. F. Piacentini, S. Sarre, Y. Michotte, T. Ishiwata, and R. Meeusen
Influence of brain catecholamines on the development of fatigue in exercising rats in the heat
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[Abstract] [Full Text] [PDF]


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