Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

J Appl Physiol (June 27, 2003). doi:10.1152/japplphysiol.00432.2003
This Article
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
95/4/1560    most recent
00432.2003v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kairaitis, K.
Right arrow Articles by Amis, T. C
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kairaitis, K.
Right arrow Articles by Amis, T. C
Submitted on April 30, 2003
Accepted on June 18, 2003

Upper airway extraluminal tissue pressure fluctuations during breathing in rabbits

Kristina Kairaitis1*, Radha Parikh2, Rosie Stavrinou2, Sarah Garlick2, Jason P Kirkness1, John R Wheatley1, and Terence C Amis1

1 Ludwig Engel Centre for Respiratory Research, Westmead Hospital, Sydney, NSW, Australia; University of Sydney, Sydney, NSW, Australia
2 University of Sydney, Sydney, NSW, Australia

* To whom correspondence should be addressed. E-mail: kristinak{at}westgate.wh.usyd.edu.au.

Transmural pressure at any level in the upper airway is dependent on the difference between intraluminal airway and extraluminal tissue pressure (ETP). We hypothesised that ETP would be affectd by topography, head/neck position, resistive loading and stimulated breathing on ETP in rabbits. Methods: Twenty eight male, NZ White, anesthetised, spontaneously breathing rabbits breathed via a face mask with attached pneumotachograph to measure airflow (V) and pressure transducer to monitor mask pressure (PM). Tidal volume (VT) was measured via integration of the V signal. ETP was measured with a pressure transducer tipped catheter inserted in the tissues of the lateral (ETPlat, n=28) and anterior (ETPant, n=21), pharyngeal wall. Head position was controlled at 30°, 50° or 70° and the effect of addition of an external resistor, brief occlusion, or stimulated breathing examined. Results: Mean ETPlat was ~0.7 cm H2O greater than mean ETPant when adjusted for degree of head/neck flexion (p<0.05). Mean, maximum and minimum ETP values increased significantly by 0.7 to 0.8 cmH2O per 20° of head/neck flexion when adjusted for site of measurement (p<0.0001). The main effect of resistive loading/occlusion was an increase in {Delta}ETPlat (maximum-minimum ETPlat) and {Delta}ETPant at all head/neck positions (p<0.05). Mean ETPlat and ETPant increased with increasing tidal volume at head/neck position 30° (all p<0.05). Conclusion: ETP was non-homogeneously distributed around the upper airway and increased with both increasing head/neck flexion and increasing VT. Brief airway occlusion increased the size of respiratory related ETP fluctuations in upper airway ETP.




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
A. Liu, L. Pichard, H. Schneider, S. P. Patil, P. L. Smith, V. Polotsky, and A. R. Schwartz
Neuromechanical control of the isolated upper airway of mice
J Appl Physiol, October 1, 2008; 105(4): 1237 - 1245.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. P. Kirkness, A. R. Schwartz, H. Schneider, N. M. Punjabi, J. J. Maly, A. M. Laffan, B. M. McGinley, T. Magnuson, M. Schweitzer, P. L. Smith, et al.
Contribution of male sex, age, and obesity to mechanical instability of the upper airway during sleep
J Appl Physiol, June 1, 2008; 104(6): 1618 - 1624.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. Amatoury, L. Howitt, J. R. Wheatley, A. P. Avolio, and T. C. Amis
Snoring-related energy transmission to the carotid artery in rabbits
J Appl Physiol, May 1, 2006; 100(5): 1547 - 1553.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. Kairaitis, R. Stavrinou, R. Parikh, J. R. Wheatley, and T. C. Amis
Mandibular advancement decreases pressures in the tissues surrounding the upper airway in rabbits
J Appl Physiol, January 1, 2006; 100(1): 349 - 356.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1966 by the American Physiological Society.