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Articles in PresS, published online ahead of print March 15, 2002
J Appl Physiol, 10.1152/jap.00421.2001
Submitted on May 2, 2001
Accepted on March 8, 2002
1 Department of Anesthesiology and Physiology, Medical College of Wisconsin, Milwaukee, WI, USA; VA Medical Center, Milwaukee, WI, USA
* To whom correspondence should be addressed. E-mail: pcliff{at}mcw.edu.
These experiments tested the hypothesis that elevating muscle blood flow prior to exercise would wash out vasoactive substances produced by muscle contraction and reduce the magnitude of exercise hyperemia and/or delay the response. In chronically instrumented dogs (n=7), hindlimb blood flow was measured with chronically implanted flowprobes during mild treadmill exercise. In an anesthetized preparation (n=8), arterial and venous blood flows of a single hindlimb were obtained during 1 sec tetanic contractions evoked by electrical stimulation of the cut sciatic nerve. Elevation of blood flow by intraarterial infusion of adenosine attenuated the increase in flow during exercise and tetanic contraction by 48% and 47%, respectively. No delay was observed in the latency to peak flow. The attenuated hyperemic response to exercise or contraction is best explained by washout of vasoactive substance(s) produced by contracting muscle, but the residual response suggests that a metabolic mediator may not be the sole explanation for exercise hyperemia.
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