| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Kinesiology, University of Maryland, College Park, Maryland, United States; Kinesiology, Towson University, Towson, Maryland, United States
2 Research Center for Genetic Medicine, Childrens National Medical Center, Washington, District of Columbia, United States; Kinesiology, University of Maryland, College Park, Maryland, United States
3 Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States
4 Kinesiology, University of Maryland, College Park, Maryland, United States; Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States
5 Avain and Animal Science, University of Maryland, College Park, Maryland, United States
6 Kinesiology, University of Maryland, College Park, Maryland, United States
7 Department of Kinesiology, University of Maryland, College Park,, Maryland, United States
8 Department of Kinesiology, University of Maryland, College Park, Maryland, United States
* To whom correspondence should be addressed. E-mail: benhur{at}umd.edu.
To examine the influence of IGF pathway gene polymorphisms on muscle mass and strength responses to strength training (ST), we studied 128 Caucasian and African American men and women before and after a 10-wk single-leg knee extension ST program. One-repetition maximum (1 RM) strength, muscle volume (MV) via computed tomography, and muscle quality (MQ) were assessed at baseline and after 10 wk of ST. There was a significant combined IGF1 CA repeat gene effect, which includes both the IGF1 CA repeat main effect and IGF1 CA repeat X PPP3R1 I/D gene X gene interaction effect, on the changes in strength (P < 0.01) and MQ (P < 0.05) with ST. There was a trend for a significant gene X gene interaction between IGF1 CA repeat and PPP3R1 I/D for changes in strength (P = 0.07) and MQ (P = 0.06) with ST. The influence of the PPP3R1 A-202C gene polymorphism on change in MV with ST approached significance (P = 0.06). The IGF1 CA repeat polymorphism had a significant influence on the change in strength and MV combined with ST (P < 0.05), while the influence of the PPP3R1 I/D polymorphism approached significance (P = 0.08). There were no associations between the IGFBP3 A-202C gene polymorphism and the muscle phenotypic responses to ST. These data suggest that two of the three IGF pathway gene polymorphisms identified in this study influence muscle phenotypic responses to ST in both African American and Caucasian older men and women.
This article has been cited by other articles:
|
|
 |
|
  S. Walsh, B. K. Kelsey, T. J. Angelopoulos, P. M. Clarkson, P. M. Gordon, N. M. Moyna, P. S. Visich, R. F. Zoeller, R. L. Seip, S. Bilbie, et al. CNTF 1357 G -> A polymorphism and the muscle strength response to resistance training J Appl Physiol, October 1, 2009; 107(4): 1235 - 1240. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
