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1 Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO, USA
2 Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA
* To whom correspondence should be addressed. E-mail: leinwand{at}ataqdog.colorado.edu.
We examined voluntary wheel running and forced treadmill running exercise performance of wild type mice and mice null for the desmin gene. When given access to a cage wheel, desmin null mice spent less time running and ran less far than wild type mice. Wild type mice showed a significant training effect with prolonged voluntary wheel running, as evidenced by an increase in mean running speed across the 3-week exercise period, while desmin null mice did not. Desmin null mice also performed less well in acute treadmill stress and endurance tests compared to wild type mice. We also evaluated serum creatine kinase (CK) activity in wild type and desmin null mice in response to running. Voluntary running did not result in elevated CK activity in either wild type or desmin null mice, while downhill treadmill running caused significant increases in serum CK activity in both wild type and desmin null mice. However, the increase in serum CK was significantly less in desmin null mice than in wild-type mice. These results suggest that the lack of desmin adversely affects the ability of mice to engage in both chronic and acute bouts of endurance running exercise, but that this decrement in performance is not associated with an increase in serum CK activity.
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