| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Articles in PresS, published online ahead of print October 11, 2002
J Appl Physiol, 10.1152/jap.00408.2002
Submitted on May 10, 2002
Accepted on September 3, 2002
1 Department of Physiology, St. Marianna University, Kawasaki, Kanagawa, Japan
2 School of Health and Sport Sciences, Osaka University, Toyonaka, Osaka, Japan
3 Department of Physiology, St. Marianna University, Kawasaki, Kanagawa, Japan; Aomori University of Health and Welfare, Aomori, Aomori, Japan
* To whom correspondence should be addressed. E-mail: ohira{at}space.hss.osaka-u.ac.jp.
Responses of the properties of connectin molecules in the slow-twitch soleus (SOL) and fast-twitch extensor digitorum longus (EDL) muscles of rats to 3 days of unloading with or without 3-day reloading were investigated. The wet weight (relative to body weight) of SOL, not of EDL, in the unloaded group was significantly less than the age-matched control (p<0.05). Immunoelectron microscopic analyses showed that a monoclonal antibody against connectin (SM1) bound to the I-band region close to the edge of the A-band at resting length and moved reversibly away from the Z-line as the muscle fibers were stretched. In SOL, the displacement of the SM1-bound dense spots in response to stretching decreased following hindlimb suspension. There were no changes in the molecular weights and the percent distributions of 
- and ß -connectin in both muscles following hindlimb suspension. A significant increment of percent ß -connectin in SOL was observed after 3-day reloading following hindlimb suspension (p<0.05). It is suggested that the elasticity of connectin filaments in the I-band region of the atrophied SOL fibers was reduced relative to that of the control. The lack of the elasticity in atrophied muscle fibers may cause a decrease in contractile function.
This article has been cited by other articles:
|
|
 |
|
  J. J. Widrick, G. F. Maddalozzo, H. Hu, J. C. Herron, U. T. Iwaniec, and R. T. Turner Detrimental effects of reloading recovery on force, shortening velocity, and power of soleus muscles from hindlimb-unloaded rats Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2008; 295(5): R1585 - R1592. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Udaka, S. Ohmori, T. Terui, I. Ohtsuki, S. Ishiwata, S. Kurihara, and N. Fukuda Disuse-induced Preferential Loss of the Giant Protein Titin Depresses Muscle Performance via Abnormal Sarcomeric Organization J. Gen. Physiol., December 31, 2007; 131(1): 33 - 41. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. G. Prado, I. Makarenko, C. Andresen, M. Kruger, C. A. Opitz, and W. A. Linke Isoform Diversity of Giant Proteins in Relation to Passive and Active Contractile Properties of Rabbit Skeletal Muscles J. Gen. Physiol., October 31, 2005; 126(5): 461 - 480. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Kawano, A. Ishihara, J. L. Stevens, X. D. Wang, S. Ohshima, M. Horisaka, Y. Maeda, I. Nonaka, and Y. Ohira Tension- and afferent input-associated responses of neuromuscular system of rats to hindlimb unloading and/or tenotomy Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2004; 287(1): R76 - R86. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
