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Articles in PresS, published online ahead of print August 16, 2002
J Appl Physiol, 10.1152/jap.00405.2002
Submitted on May 8, 2002
Accepted on August 15, 2002
1 Division of Sleep Medicine, Brigham and Woman's Hospital, Harvard Medical School, Boston, MA, USA
* To whom correspondence should be addressed. E-mail: lling{at}partners.org.
Episodic hypoxia induces a persistent augmentation of respiratory activity, termed long-term facilitation (LTF). Phrenic LTF saturates in anesthetized animals, such that additional episodes of stimulation cause no further increase in LTF magnitude. The present study tested the hypothesis that 1) ventilatory LTF also saturates in awake rats and 2) more severe hypoxia and hypoxic episodes increase the effectiveness of eliciting ventilatory LTF. Minute ventilation was measured in awake, male Sprague-Dawley rats by plethysmography. LTF was elicited by 5 episodes of 10% O2 poikilocapnic hypoxia (magnitude: 17.3 ± 2.8% above baseline, between 15 - 45-min post-hypoxia, duration: 45-min) but not 12% or 8% O2. LTF was also elicited by 10, 20 and 72 episodes of 12% O2 (19.1 ± 2.2%, 18.9 ± 1.8% and 19.8 ± 1.6%; 45, 60 and 75-min, respectively) but not by 3 or 5 episodes. These results show that there is a certain range of hypoxia that induces ventilatory LTF and that additional hypoxic episodes may increase the duration but not the magnitude of this response.
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