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-1 in relation to exercise-induced type I collagen synthesis in human tendinous tissue
1 Sports Medicine Research Unit, Bispebjerg Hospital, Copenhagen, Denmark
* To whom correspondence should be addressed. E-mail: KH08{at}bbh.hosp.dk.
Mechanical loading of tissue is known to influence local collagen synthesis, and microdialysis studies indicate that mechanical loading of human tendon during exercise elevates tendinous type I collagen production. Transforming growth factor-b-1 (TGF-
-1)- a potent stimulator of type I collagen synthesis- is released from cultured tendon fibroblasts in response to mechanical loading. Thus, TGF--1 could link mechanical loading and collagen synthesis in tendon tissue in vivo. Tissue levels of TGF--1 and type I collagen metabolism markers (PICP and ICTP) were measured by microdialysis in the peritendinous tissue of the Achilles' tendon in 6 male volunteers prior to and following treadmill running (1 h, 12 km/h, 3% uphill). In addition, blood levels of TGF--1, PICP and ICTP were obtained. PICP levels increased 68 hours after exercise (p<0.05). Dialysate levels of TGF--1 changed from 303 ± 46 pg/ml (at rest) to 423 ± 86 pg/ml three hours post exercise. This change was non-significant, but the decay of tissue TGF--1 after catheter insertion was markedly delayed by exercise compared to the decay seen in resting subjects. Plasma concentrations of TGF--1 rose 30% in response to exercise (p<0.05 vs pre). Our observations indicate an increased local production of type I collagen in human peritendinous tissue in response to uphill running. Though not conclusive, changes in circulating and local TGF--1, in response to exercise, suggest a role for TGF--1 in mechanical regulation of local collagen type I synthesis in tendon related connective tissue in vivo.
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