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1 Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
2 Department of Cardiovascular and Thoracic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA
* To whom correspondence should be addressed. E-mail: Connie.Hsia{at}utsouthwestern.edu.
Following pneumonectomy (PNX), mechanical strain on the remaining lung is greatly increased. To assess if remaining lobes expand uniformly following left or right PNX (removing 42% and 58% of lung mass, respectively), we performed high resolution computed tomography (CT) scans at 45 ml/kg above end-expiratory lung volume on adult male foxhounds following left or right PNX compared to adult sham controls. Air and parenchyma volumes were separately measured in each lobe. Following left PNX, air and parenchyma volume in the right upper and cardiac lobes increased ~2.2-fold above and below the heart, while volumes in right middle and lower lobes did not change significantly. Following right PNX, air and parenchyma volumes in the left upper and middle lobes increased 2.3 to 2.7-fold across the midline anterior to the heart while the left lower lobe expanded ~1.9-fold posterior to the heart. Regional changes in volume density of parenchyma post-PNX estimated by CT scan parallel post-mortem estimates by morphometric analysis. Data indicate heterogeneous regional distribution of mechanical lung strain, which could influence differential cellular compensatory response following right and left PNX. Retinoic acid administered to some post-PNX animals as part of a separate study had no significant effect on regional volumes.
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