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1 Metabolic Research Centre, University of Wollongong, Wollongong, NSW, Australia; Department of Biomedical Science, University of Wollongong, Wollongong, NSW, Australia; Department of Chemistry, University of Wollongong, Wollongong, NSW, Australia
2 Metabolic Research Centre, University of Wollongong, Wollongong, NSW, Australia; Department of Biomedical Science, University of Wollongong, Wollongong, NSW, Australia
3 Metabolic Research Centre, University of Wollongong, Wollongong, NSW, Australia; School of Biological Sciences, University of Wollongong, Wollongong, NSW, Australia
4 School of Medical Sciences, RMIT University, Bundoora, Victoria, Australia
5 Department of Chemistry, University of Wollongong, Wollongong, NSW, Australia
* To whom correspondence should be addressed. E-mail: toddm{at}uow.edu.au.
We have determined the effect of two exercise training intensities on membrane phospholipids of both glycolytic and oxidative muscle fibers of female Sprague-Dawley rats using electrospray-ionization mass spectrometry (ESI-MS). Animals were randomly divided into three training groups: control, which performed no exercise training; low intensity (8 m min-1) treadmill running; or high intensity (28 m min-1) treadmill running. All exercise-trained rats ran 1000 m session-1, 4 days wk-1 for 4 wks and were killed 48 h after the last training bout. Exercise training was found to produce no novel phospholipid species but was associated with significant alterations in the relative abundance of a number of phospholipid molecular species. These changes were more prominent in glycolytic (white vastus lateralis) than in oxidative (red vastus lateralis) muscle fibers. The largest observed change was a decrease of approximately 20 % in the abundance of 1-stearoyl-2-docosahexaenoyl phosphatidylethanolamine (PE(18:0,22:6), P<0.001) ions in both the low and high intensity training regimes in glycolytic fibers. Increases in the abundance of 1-oleoyl-2-linoleoyl phopshatidic acid (PA(18:1,18:2), P<0.001) and 1-alkenylpalmitoyl-2-linoleoyl phosphatidylethanolamine (Plasmenyl PE(16:0,18:2), P<0.005) ions were also observed for both training regimes in glycolytic fibers. We conclude that exercise training results in a remodeling of phospholipids in rat skeletal muscle. Even though little is known about the physiological or pathophysiological role of specific membrane phospholipid molecular species it is likely that this remodeling will have an impact upon a range of cellular functions.
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