Submitted on April 1, 2009
Revised on May 4, 2009
Accepted on May 6, 2009
The interactions of some commonly consumed drugs with mitochondrial adaptations to exercise
Matthew M. Robinson1, Karyn L. Hamilton1, and Benjamin F. Miller1*
1 Colorado State University
* To whom correspondence should be addressed. E-mail: bfmiller{at}cahs.colostate.edu.
The importance of mitochondrial dysfunctions in the progression of chronic disease has been well established. Patients with chronic diseases are often prescribed a variety of medications, many of which have been shown to induce mitochondrial dysfunction. Exercise is a known stimulus for mitochondrial biogenesis and also recommended to patients as a lifestyle modification to supplement drug therapy. However, the potential interference of those drugs with mitochondrial adaptations to exercise has not been thoroughly investigated. This review provides a summary and discussion of known and potential interactions of commonly consumed drugs with exercise induced mitochondrial adaptations.
