| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Articles in PresS, published online ahead of print August 16, 2002
J Appl Physiol, 10.1152/jap.00337.2002
Submitted on April 15, 2002
Accepted on August 14, 2002
1 Anesthesiology and Physiology, Medical College of Wisconsin, Milwaukee, WI, USA; VA Medical Center, Milwaukee, WI, USA
* To whom correspondence should be addressed. E-mail: pcliff2mcw.edu.
The muscle pump theory holds that contraction aids muscle perfusion by emptying the venous circulation which lowers venous pressure during relaxation and increases the pressure gradient across the muscle. We reasoned that the influence of a reduction in venous pressure could be determined following maximal pharmacologic vasodilation where the changes in vascular tone would be minimized. Mongrel dogs (n=7), instrumented for measurement of hindlimb blood flow, ran on a treadmill during continuous intraarterial infusion of saline or adenosine (15-35mg/min). Adenosine infusion was initiated at rest to achieve the highest blood flow possible. Peak hindlimb blood flow during exercise increased from baseline by 438±34 ml/min under saline conditions, but decreased by 27±18 ml/min during adenosine infusion. The absence of an increase in blood flow in the vasodilated limb indicates that any change in venous pressure elicited by the muscle pump was not adequate to elevate hindlimb blood flow. The implication of this finding is that the hyperemic response to exercise is primarily attributable to vasodilation in the skeletal muscle vasculature.
This article has been cited by other articles:
|
|
 |
|
  J. Gonzalez-Alonso, S. P. Mortensen, T. D. Jeppesen, L. Ali, H. Barker, R. Damsgaard, N. H. Secher, E. A. Dawson, and S. P. Dufour Haemodynamic responses to exercise, ATP infusion and thigh compression in humans: insight into the role of muscle mechanisms on cardiovascular function J. Physiol., May 1, 2008; 586(9): 2405 - 2417. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. F. Ferreira, D. J. Padilla, T. I. Musch, and D. C. Poole Temporal profile of rat skeletal muscle capillary haemodynamics during recovery from contractions J. Physiol., June 15, 2006; 573(3): 787 - 797. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Tschakovsky The muscle pump debate: selective literature representations. J Appl Physiol, August 1, 2005; 99(2): 771 - 771. [Full Text] [PDF]
|
|
|
|
|
|
D. Sheriff, P. S. Clifford, J. J. Hamann, Z. Valic, and J. B. Buckwalter Point: The muscle pump raises muscle blood flow during locomotion J Appl Physiol, July 1, 2005; 99(1): 371 - 375. [Full Text] [PDF]
|
|
|
|
|
|
B. J. Lutjemeier, A. Miura, B. W. Scheuermann, S. Koga, D. K. Townsend, and T. J. Barstow Muscle contraction-blood flow interactions during upright knee extension exercise in humans J Appl Physiol, April 1, 2005; 98(4): 1575 - 1583. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Valic, J. B. Buckwalter, and P. S. Clifford Muscle blood flow response to contraction: influence of venous pressure J Appl Physiol, January 1, 2005; 98(1): 72 - 76. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. R. Saunders and M. E. Tschakovsky Evidence for a rapid vasodilatory contribution to immediate hyperemia in rest-to-mild and mild-to-moderate forearm exercise transitions in humans J Appl Physiol, September 1, 2004; 97(3): 1143 - 1151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Tschakovsky and D. D. Sheriff Immediate exercise hyperemia: contributions of the muscle pump vs. rapid vasodilation J Appl Physiol, August 1, 2004; 97(2): 739 - 747. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. S. Clifford and Y. Hellsten Vasodilatory mechanisms in contracting skeletal muscle J Appl Physiol, July 1, 2004; 97(1): 393 - 403. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Hamann, J. B. Buckwalter, and P. S. Clifford Vasodilatation is obligatory for contraction-induced hyperaemia in canine skeletal muscle J. Physiol., June 15, 2004; 557(3): 1013 - 1020. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Hamann, J. B. Buckwalter, P. S. Clifford, and J. K. Shoemaker Is the blood flow response to a single contraction determined by work performed? J Appl Physiol, June 1, 2004; 96(6): 2146 - 2152. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Hogan, B. Grassi, M. Samaja, C. M. Stary, and L. B. Gladden Effect of contraction frequency on the contractile and noncontractile phases of muscle venous blood flow J Appl Physiol, September 1, 2003; 95(3): 1139 - 1144. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. H. Laughlin and M. Joyner Closer to the edge? Contractions, pressures, waterfalls and blood flow to contracting skeletal muscle J Appl Physiol, January 1, 2003; 94(1): 3 - 5. [Full Text] [PDF]
|
|
|
|
|
|
J. L. Dobson and L. B. Gladden Effect of rhythmic tetanic skeletal muscle contractions on peak muscle perfusion J Appl Physiol, January 1, 2003; 94(1): 11 - 19. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
