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J Appl Physiol (August 23, 2002). doi:10.1152/japplphysiol.00334.2002
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Articles in PresS, published online ahead of print August 23, 2002
J Appl Physiol, 10.1152/jap.00334.2002
Submitted on April 15, 2002
Accepted on August 16, 2002

Activation of thalamic ventroposteriorlateral neurons by phrenic nerve afferents in cats and rats

Weirong Zhang1 and Paul W Davenport1*

1 Department of Physiological Sciences, University of Florida, Gainesville, Florida, USA

* To whom correspondence should be addressed. E-mail: davenportp{at}mail.vetmed.ufl.edu.

It has been demonstrated that phrenic nerve afferents project to somatosensory cortex, yet, the sensory pathways are still poorly understood. This study investigated the neural responses in the thalamic ventroposteriorlateral (VPL) nucleus following phrenic afferents stimulation in cats and rats. Activation of VPL neurons was observed following electrical stimulation of the contralateral phrenic nerve. Direct mechanical stimulation of the diaphragm also elicited increased activity in same VPL neurons that were activated by electrical stimulation of phrenic nerve. Some VPL neurons responded to both phrenic afferents stimulation and shoulder probing. In rats, VPL neurons activated by inspiratory occlusion also responded to stimulation on phrenic afferents. These results demonstrate that phrenic afferents can reach VPL thalamus under physiological conditions, and support the hypothesis that the thalamic VPL nucleus functions as a relay for the conduction of proprioceptive information from the diaphragm to the contralateral somatosensory cortex.




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