| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Metabolism Unit, Department of Surgery, Shriners Hospitals for Children/Galveston, University of Texas Medical Branch, Galveston, TX, USA
* To whom correspondence should be addressed. E-mail: rwolfe{at}utmb.edu.
The purpose of this study was to determine the effect of ingestion of 100 g of carbohydrates on net muscle protein balance (protein synthesis minus protein breakdown) after resistance exercise. Two groups of eight subjects performed a resistance exercise bout (10 sets of 8 repetitions of leg presses at 80% of one-repetition maximum) before they rested in bed for four hours. One group (CHO) received a drink consisting of 100 g of carbohydrates 1 h post-exercise. The other group (PLA) received a non-caloric placebo drink. Leg amino acid metabolism was determined by infusion of 2H5- or 13C6-phenylalanine, sampling from femoral artery and vein, and muscle biopsies from vastus lateralis. Drink intake did not affect arterial insulin concentration in PLA, whereas insulin increased several-fold after the drink in CHO (P < 0.05 vs. PLA). Arterial phenylalanine concentration fell slightly after the drink in CHO. Net muscle protein balance did not change in PLA, whereas it improved in CHO from -17 ± 3 nmol.ml-1.100 ml leg-1 before drink to an average of -4 ± 4 and 0 ± 3 nmol.ml-1.100 ml leg-1 during the second and third h after the drink, respectively (P < 0.05 vs. PLA during last h). The improved net balance in CHO was due primarily to a progressive decrease in muscle protein breakdown. We conclude that ingestion of carbohydrates improved net leg protein balance following resistance exercise. However, the effect was minor and delayed compared to the previously reported effect of ingestion of amino acids.
This article has been cited by other articles:
|
|
 |
|
  R. Koopman and L. J. C. van Loon Aging, exercise, and muscle protein metabolism J Appl Physiol, June 1, 2009; 106(6): 2040 - 2048. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Kumar, P. Atherton, K. Smith, and M. J. Rennie Human muscle protein synthesis and breakdown during and after exercise J Appl Physiol, June 1, 2009; 106(6): 2026 - 2039. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. A. Burd, J. E. Tang, D. R. Moore, and S. M. Phillips Exercise training and protein metabolism: influences of contraction, protein intake, and sex-based differences J Appl Physiol, May 1, 2009; 106(5): 1692 - 1701. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Beelen, M. Tieland, A. P. Gijsen, H. Vandereyt, A. K. Kies, H. Kuipers, W. H. M. Saris, R. Koopman, and L. J. C. van Loon Coingestion of Carbohydrate and Protein Hydrolysate Stimulates Muscle Protein Synthesis during Exercise in Young Men, with No Further Increase during Subsequent Overnight Recovery J. Nutr., November 1, 2008; 138(11): 2198 - 2204. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Beelen, R. Koopman, A. P. Gijsen, H. Vandereyt, A. K. Kies, H. Kuipers, W. H. M. Saris, and L. J. C. van Loon Protein coingestion stimulates muscle protein synthesis during resistance-type exercise Am J Physiol Endocrinol Metab, July 1, 2008; 295(1): E70 - E77. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Manders, R. Koopman, M. Beelen, A. P. Gijsen, W. K. Wodzig, W. H. Saris, and L. J. van Loon The Muscle Protein Synthetic Response to Carbohydrate and Protein Ingestion Is Not Impaired in Men with Longstanding Type 2 Diabetes J. Nutr., June 1, 2008; 138(6): 1079 - 1085. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Morrison, D. Hara, Z. Ding, and J. L. Ivy Adding protein to a carbohydrate supplement provided after endurance exercise enhances 4E-BP1 and RPS6 signaling in skeletal muscle J Appl Physiol, April 1, 2008; 104(4): 1029 - 1036. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. C. Dreyer, M. J. Drummond, B. Pennings, S. Fujita, E. L. Glynn, D. L. Chinkes, S. Dhanani, E. Volpi, and B. B. Rasmussen Leucine-enriched essential amino acid and carbohydrate ingestion following resistance exercise enhances mTOR signaling and protein synthesis in human muscle Am J Physiol Endocrinol Metab, February 1, 2008; 294(2): E392 - E400. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. Tang, J. G. Perco, D. R. Moore, S. B. Wilkinson, and S. M. Phillips Resistance training alters the response of fed state mixed muscle protein synthesis in young men Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2008; 294(1): R172 - R178. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Koopman, M. Beelen, T. Stellingwerff, B. Pennings, W. H. M. Saris, A. K. Kies, H. Kuipers, and L. J. C. van Loon Coingestion of carbohydrate with protein does not further augment postexercise muscle protein synthesis Am J Physiol Endocrinol Metab, September 1, 2007; 293(3): E833 - E842. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. W Hartman, J. E Tang, S. B Wilkinson, M. A Tarnopolsky, R. L Lawrence, A. V Fullerton, and S. M Phillips Consumption of fat-free fluid milk after resistance exercise promotes greater lean mass accretion than does consumption of soy or carbohydrate in young, novice, male weightlifters Am. J. Clinical Nutrition, August 1, 2007; 86(2): 373 - 381. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Jeyapalan, R. A. Orellana, A. Suryawan, P. M. J. O'Connor, H. V. Nguyen, J. Escobar, J. W. Frank, and T. A. Davis Glucose stimulates protein synthesis in skeletal muscle of neonatal pigs through an AMPK- and mTOR-independent process Am J Physiol Endocrinol Metab, August 1, 2007; 293(2): E595 - E603. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A H Manninen Hyperinsulinaemia, hyperaminoacidaemia and post-exercise muscle anabolism: the search for the optimal recovery drink Br. J. Sports Med., November 1, 2006; 40(11): 900 - 905. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Koopman, L. Verdijk, R. J. Manders, A. P Gijsen, M. Gorselink, E. Pijpers, A. J. Wagenmakers, and L. J. van Loon Co-ingestion of protein and leucine stimulates muscle protein synthesis rates to the same extent in young and elderly lean men. Am. J. Clinical Nutrition, September 1, 2006; 84(3): 623 - 632. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Olsen, P. Aagaard, F. Kadi, G. Tufekovic, J. Verney, J. L. Olesen, C. Suetta, and M. Kjaer Creatine supplementation augments the increase in satellite cell and myonuclei number in human skeletal muscle induced by strength training J. Physiol., June 1, 2006; 573(2): 525 - 534. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Katsanos, D. L. Chinkes, M. Sheffield-Moore, A. Aarsland, H. Kobayashi, and R. R. Wolfe Method for the determination of the arteriovenous muscle protein balance during non-steady-state blood and muscle amino acid concentrations Am J Physiol Endocrinol Metab, December 1, 2005; 289(6): E1064 - E1070. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sheffield-Moore, D. Paddon-Jones, A. P. Sanford, J. I. Rosenblatt, A. G. Matlock, M. G. Cree, and R. R. Wolfe Mixed muscle and hepatic derived plasma protein metabolism is differentially regulated in older and younger men following resistance exercise Am J Physiol Endocrinol Metab, May 1, 2005; 288(5): E922 - E929. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Koopman, A. J. M. Wagenmakers, R. J. F. Manders, A. H. G. Zorenc, J. M. G. Senden, M. Gorselink, H. A. Keizer, and L. J. C. van Loon Combined ingestion of protein and free leucine with carbohydrate increases postexercise muscle protein synthesis in vivo in male subjects Am J Physiol Endocrinol Metab, April 1, 2005; 288(4): E645 - E653. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Paddon-Jones, M. Sheffield-Moore, R. J. Urban, A. Aarsland, R. R. Wolfe, and A. A. Ferrando The Catabolic Effects of Prolonged Inactivity and Acute Hypercortisolemia Are Offset by Dietary Supplementation J. Clin. Endocrinol. Metab., March 1, 2005; 90(3): 1453 - 1459. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Paddon-Jones, M. Sheffield-Moore, R. J. Urban, A. P. Sanford, A. Aarsland, R. R. Wolfe, and A. A. Ferrando Essential Amino Acid and Carbohydrate Supplementation Ameliorates Muscle Protein Loss in Humans during 28 Days Bedrest J. Clin. Endocrinol. Metab., September 1, 2004; 89(9): 4351 - 4358. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
