This study examined the acute effects of maximum strength (MS), muscular hypertrophy (MH), and strength endurance (SE) resistance exercise protocols on serum leptin. Ten young lean males (age=23±4 yrs; BW=79.6±5.2 kg; body fat=10.2±3.9 %) participated in MS (4 sets x 5 reps at 88 % of 1-RM with 3 min rest between sets), MH (4 sets x 10 reps at 75% of 1-RM with 2 min rest between sets), SE (4 sets x 15 reps at 60% of 1-RM with 1 min rest between sets) and control (C) sessions. Blood samples were collected before and immediately after exercise, and after 30 min of recovery. Serum leptin at 30 min of recovery exhibited similar reductions from baseline following MS (-20±5%), MH (-20±4%), and SE (-15±6%) protocols that were comparable to fasting-induced reduction in C (-12±3%) session (p<0.05). Furthermore, no differences were found in serum leptin among the MS, MH and SE and C sessions immediately after exercise and at 30 min of recovery (p>0.05). Cortisol was higher (p<0.05) after MH and SE protocols than after MS and C sessions. Glucose and GH were higher (p<0.05) after exercise in the MS, MH and SE protocols than after C session. In conclusion, typical resistance exercise protocols designed for development of maximum strength, muscular hypertrophy, and strength endurance, did not result in serum leptin changes when sampled immediately or 30 min post-exercise.