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J Appl Physiol (August 30, 2002). doi:10.1152/japplphysiol.00315.2002
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Articles in PresS, published online ahead of print August 30, 2002
J Appl Physiol, 10.1152/jap.00315.2002
Submitted on April 10, 2002
Accepted on August 23, 2002

DECLINE IN INSULIN ACTION WITH AGE IN ENDURANCE-TRAINED HUMANS

Christopher M Clevenger1, Pamela Parker Jones1, Hirofumi Tanaka1, Douglas R Seals2, and Christopher A DeSouza3*

1 Department of Kinesiology and Applied Physiology, University of Colorado, Boulder, CO, USA
2 Department of Kinesiology and Applied Physiology, University of Colorado, Boulder, CO, USA; Department of Medicine, Geriatric Medicine, University of Colorado Health Sciences Center, Denver, CO, USA; Department of Cardiology, University of Colorado Health Sciences Center, Denver, CO, USA
3 Department of Kinesiology and Applied Physiology, University of Colorado, Boulder, CO, USA; Department of Medicine, Geriatric Medicine, University of Colorado Health Sciences Center, Denver, CO, USA

* To whom correspondence should be addressed. E-mail: desouzac{at}colorado.edu.

We tested the hypothesis that regular-endurance exercise prevents the age-related decline in insulin action typically observed in healthy, sedentary adults. An index of whole-body insulin sensitivity (SI), obtained from minimal model analysis of insulin and glucose concentrations during a frequently sampled intravenous glucose tolerance test, was determined in 126 healthy adults: 25 young (27±1 yr; 13 male/12 female) and 43 older (59±1; 20/13) sedentary, and 25 young (29±1; 12/13) 33 older (60±1; 20/13) endurance-trained. SI values were lower in the older vs young adults in both sedentary (-53%; 3.9±0.3 vs 7.0±0.7 • 10-4 min-1/µU/mL, P<0.01) and endurance-trained (-36%; 7.9±0.6 vs 12.4±1.0 • 10-4 min-1/µU/mL, P<0.01) groups, but was 72-102% higher in the trained subjects at either age (P<0.01). In subgroup analysis of sedentary and endurance-trained adults with similar body fat levels (n=62) the age-related reduction in SI persisted only in the endurance-trained subjects (12.9±1.9 vs 8.7±1.2 • 10-4 min-1/µU/mL, P<0.01). The results of the present study suggest that habitual endurance exercise does not prevent the age-associated decline insulin action. Moreover, the age-related reduction in SI in endurance-trained adults appears to be independent of adiposity.




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