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1 Department of Physiology, Graduate School of Health Sciences, Hiroshima University, Hiroshima, Hiroshima, Japan
* To whom correspondence should be addressed. E-mail: matsuk{at}hiroshima-u.ac.jp.
Animals decerebrated at the precollicular-premammillary body level exhibit spontaneous locomotion without any artificial stimulation. We reported that the cardiovascular and autonomic responses at the onset of spontaneous locomotor events are evoked by central command, generated from the caudal diencephalon and the brain stem (Matsukawa et al, Am J Physiol 275: H1115-H1121, 1998). In this study we examined if central command and/or a reflex resulting from muscle afferents modulates arterial baroreflex function using a decerebrate cat model. The baroreflex was evoked by stimulating the aortic depressor nerve (ADN) at the onset of spontaneous muscle contraction (to test the possible influence of central command) and during electrically-evoked contraction or passive stretch (to test the possible influence of the muscle reflex). When the ADN was stimulated at rest, heart rate and arterial blood pressure decreased by 40±2 beats/min and 11±1 mmHg, respectively. The baroreflex bradycardia was attenuated to 55±4% at the onset of spontaneous contraction. The attenuating effect on the baroreflex bradycardia was not observed at the onset and middle of electrically-evoked contraction or passive stretch. The depressor response to ADN stimulation was identical among resting and any muscle interventions. The inhibition of the baroreflex bradycardia during spontaneous contraction was seen after 
-adrenergic blockade but abolished by muscarinic blockade, suggesting that the bradycardia is mainly evoked through cardiac vagal outflow. We conclude that central command, produced within the caudal diencephalon and the brain stem, selectively inhibits the cardiac component, but not vasomotor component, of the aortic baroreflex at the onset of spontaneous exercise.
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