| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Pediatric Respiratory Medicine, University Children's Hospital, Bern, Switzerland; Clinical Sciences Division, Institute for Child Health and Centre for Child Health Research, Perth, Western Australia, Australia
2 Department of Biomedical Engineering, Boston University, Boston, MA, USA
3 Clinical Sciences Division, Institute for Child Health and Centre for Child Health Research, Perth, Western Australia, Australia
4 Pediatric Respiratory Medicine, University Children's Hospital, Bern, Switzerland
* To whom correspondence should be addressed. E-mail: dn_baldwin{at}hotmail.com.
Deep inspirations (sighs) play a significant role in altering lung mechanical and airway wall function however their role in respiratory control remains unclear. We examined whether sighs act via a resetting mechanism to improve control of the respiratory regulatory system. Effects of sighs on system variability, short-range and long-range memory and stability were assessed in 25 healthy term infants at 1 month of age (mean 36 days, range: 28-57 days) during quiet sleep. Variability was examined using moving window coefficient of variation (CV), short-range memory with autocorrelation function and long-range memory using detrended fluctuation analysis. Stability was examined by studying the behaviour of the attractor using phase-space plots. Variability of tidal volume (VT) and minute ventilation (V'E) increased during the initial 15 breaths post-sigh. Short-range memory of (VT) decreased during the 50 breaths preceding sigh, becoming uncorrelated (random) during the 10 breath pre-sigh window. Short-range memory increased post-sigh for the entire 50 breaths when compared to the randomised dataset and for 20 breaths when compared to the pre-sigh window. Similar but shorter lasting changes were noted in (V'E). No change in long-range memory was seen after sigh. CV and range of points located within a defined attractor segment increased after sigh. Thus, control of breathing in healthy infants shows long-range stability and improvement in short-range memory and variability after sigh. These results add new evidence that the role of sighs is not purely mechanical.
This article has been cited by other articles:
|
|
 |
|
  C. Thamrin, G. Stern, M-P. F. Strippoli, C. E. Kuehni, B. Suki, D. R. Taylor, and U. Frey Fluctuation analysis of lung function as a predictor of long-term response to {beta}2-agonists Eur. Respir. J., March 1, 2009; 33(3): 486 - 493. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Engoren, S. E. Courtney, and R. H. Habib Effect of weight and age on respiratory complexity in premature neonates J Appl Physiol, March 1, 2009; 106(3): 766 - 773. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Thamrin and U. Frey Complexity and respiratory growth: a developing story J Appl Physiol, March 1, 2009; 106(3): 753 - 754. [Full Text] [PDF]
|
|
|
|
|
|
M. Kohler, S. Kriemler, E. M. Wilhelm, H. Brunner-LaRocca, M. Zehnder, and K. E. Bloch Children at high altitude have less nocturnal periodic breathing than adults Eur. Respir. J., July 1, 2008; 32(1): 189 - 197. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Fisher and S. S. Margulies Modeling the effect of stretch and plasma membrane tension on Na+-K+-ATPase activity in alveolar epithelial cells Am J Physiol Lung Cell Mol Physiol, January 1, 2007; 292(1): L40 - L53. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
