Journal of Applied Physiology AJP: Heart and Circulatory Physiology
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J Appl Physiol (October 26, 2001). doi:10.1152/japplphysiol.00296.2001
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Articles in PresS, published online ahead of print October 26, 2001
J Appl Physiol, 10.1152/jap.00296.2001
Submitted on March 27, 2001
Accepted on October 20, 2001

Gender differences in glucose kinetics and substrate oxidation during exercise near the lactate threshold

Brent C Ruby1*, Andrew R Coggan2, and Theodore W Zderic1

1 Health and Human Performance, University of Montana, Missoula, MT, USA
2 School of Medicine and GRECC, University of Maryland, Baltimore, MD, USA

* To whom correspondence should be addressed. E-mail: ruby{at}selway.umt.edu.

The purpose of this investigation was to determine plasma glucose kinetics and substrate oxidation in men and women during exercise relative to the lactate threshold. Subjects cycled for 25 minutes at 70% (70%LT) and 90% (90%LT) of the VO2 at lactate threshold. Plasma glucose appearance (Ra) and disappearance (Rd) were determined with a primed constant infusion of [6,6-2H] glucose. There were no significant differences in glucose Ra between men (22.6±1.9 and 39.9±3.9 µmol. min-1.kg FFM-1 for the 70 and 90%LT trials, respectively) and women (22.3±2.7 and 33.9±5.7 µmol. min-1.kg FFM-1 for the 70 and 90%LT trials, respectively). Similarly, there were no significant differences in glucose Rd between men (21.2±1.9 and 38.1±3.7 for the 70 and 90%LT trials, respectively) and women (21.3±2.8 and 33.3±5.6 µmol. min-1.kg FFM-1 for the 70 and 90%LT trials, respectively). Although, there were no differences between genders in the relative contribution of carbohydrate (CHO) to total energy expenditure, the relative contribution of muscle glycogen to total CHO oxidation (70% LT - M=75.8±3.2 vs. F=64.2±8.0%; 90%LT - M=75.1±2.6 vs. F=60.1±11.2%) was lower in the females. Consequently, the relative contribution of blood glucose to total CHO oxidation was significantly higher in the women. These results indicate that although plasma glucose Ra and Rd are similar between men and women, the relative contribution of muscle glycogen and blood glucose is significantly different in the female during moderate intensity exercise relative to the lactate threshold.




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