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J Appl Physiol (October 3, 2003). doi:10.1152/japplphysiol.00295.2003
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Submitted on March 21, 2003
Accepted on October 1, 2003

Reduction in heat induced gastrointestinal hyperpermeability in rats by bovine colostrum and goat milk powders

Colin Prosser1*, Kerst Stelwagen1, Robina Cummins2, Pauline Guerin2, Nick Gill2, and Chris Milne3

1 Food Science, AgResearch, Hamilton, New Zealand
2 Centre for Sport and Exercise Science, Waikato Institute of Technology, Hamilton, New Zealand
3 Clarence Street Medical, Hamilton, New Zealand

* To whom correspondence should be addressed. E-mail: colin.prosser{at}agresearch.co.nz.

Male Sprague-Dawley rats were assigned to one of three dietary groups: standard diet (CONT, n=8); standard diet plus bovine colostrum powder (BCOLOST 1.7 g/kg, n=8) or goat milk powder (GMILK 1.7 g/kg, n=8) to determine the ability of these supplements to reduce gastrointestinal hyperpermeability induced by heat. Raising core body temperature of rats to 41.5°C increased transfer of 51Cr-EDTA from gut into blood 34 fold relative to ambient temperature value (P<0.05) in CONT group of rats, indicative of increased gastrointestinal permeability. Significantly less (P<0.01) 51Cr-EDTA was transferred into blood of rats in either BCOLOST group (27% of CONT) or GMILK group (10% of CONT) after heating, showing that prior supplementation with either bovine colostrum or goat milk powder significantly reduced the impact of heat stress on gastrointestinal permeability. The changes in BCOLOST group were not significantly different than those of the GMILK group. The potential mechanism of the protective effect of bovine colostrum and goat milk powders may involve modulation of tight junction permeability as both powders were able to maintain transepithelial resistance in MDCK cells challenged with EGTA, compared with cells maintained in media only. The results show that bovine colostrum powder can partially alleviate the effects of hyperthermia on gastrointestinal permeability in the intact animal. Moreover, goat milk powder was equally as effective as bovine colostrum powder and both may be of benefit in other situations where gastrointestinal barrier function is compromised.




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