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J Appl Physiol (June 4, 2004). doi:10.1152/japplphysiol.00284.2004
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Submitted on March 19, 2004
Accepted on May 27, 2004

Epinephrine infusion increases adipose Interleukin-6 gene expression and systemic levels in humans

Pernille Keller1*, Charlotte Keller1, Lindsay E Robinson1, and Bente K Pedersen1

1 The Copenhagen Muscle Research Center and Department of Infectious Diseases, University Hospital of Copenhagen, Copenhagen, Denmark

* To whom correspondence should be addressed. E-mail: pkeller{at}rh.dk.

Exercise increases Interleukin-6 (IL-6) mRNA in subcutaneous adipose tissue, however the immediate signal for the IL-6 induction is unknown. We therefore explored the possible role of epinephrine in the induction of IL-6 in adipose tissue. Subcutaneous adipose tissue biopsies and blood samples were obtained from eight healthy men (Mean age 27 y, mean height 184 cm, mean weight 83 kg) in response to epinephrine infusion or in response to saline infusion.The rate of epinephrine infusion was such that circulating epinephrine concentrations mimicked that typically seen during exercise. The level of IL-6 mRNA in subcutaneous adipose tissue increased 26-fold (95% CI, 9-166-fold) at 3-hours of epinephrine infusion when compared with controls (P=0.028). In addition, plasma levels of IL-6 increased in response to epinephrine infusion (P<0.001). However, epinephrine affected neither TNF nor the IL-6 receptor. In conclusion, epinephrine acutely increases IL-6 mRNA levels in subcutaneous adipose tissue as well as circulating IL-6 levels in healthy men.




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