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J Appl Physiol (August 10, 2006). doi:10.1152/japplphysiol.00272.2006
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Submitted on March 2, 2006
Accepted on August 3, 2006

Effects of a progressive and maximal exercise on plasma levels of adhesion molecules in athletes with sickle cell trait with or without {alpha}-thalassemia

Geraldine Monchanin1, Laura D Serpero2, Philippe Connes1, Julien Tripette1, Dieudonne Wouassi3, Laurent Bezin4, Alain Francina5, Jeanne Ngongang6, Monica de la Pena2, Raphael Massarelli1, David Gozal2, Patrice Thiriet1, and Cyril Martin1*

1 EA 647 Center of Research and Innovation on Sports, University of Lyon 1, Villeurbanne, France
2 Kosair Childrens Hospital Research Institute, University of Louisville, Louisville, Kentucky, United States
3 National Institute of Youth and Health, Yaounde, Cameroon
4 UMR 5123 Integrative cellular and molecular physiology, University of Lyon 1, Villeurbanne, France
5 Molecular pathology of hemoglobin, Edouard Herriot Hospital, Lyon, France
6 Laboratory of Biochemicals, Medicine Faculty, University of Yaounde 1, Yaounde, Cameroon

* To whom correspondence should be addressed. E-mail: cyril.martin{at}univ-lyon.fr.

The aim of the study was to examine the effects of exercise on vascular cell adhesion molecule-1 (sVCAM-1) and intercellular adhesion molecule-1 (sICAM-1) in sickle cell trait (SCT) athletes with or without {alpha}-thalassemia. Six athletes with SCT, 7 athletes with both SCT and {alpha}-thalassemia (SCTAT) and 7 control athletes (CONT) performed an incremental and maximal test on cycloergometer. Levels of soluble sICAM-1, sVCAM-1 were assessed at rest, immediately after the end of exercise and one, two and twenty-four hours after exercise. Although, CONT and SCTAT groups exhibited similar basal plasma levels of inflammatory and adhesion molecules, SCT group had higher sVCAM-1 basal concentrations. Incremental exercise resulted in a significant increase of sVCAM-1 in all subjects, which remained elevated only in the SCT group during the recovery period. In conclusion, as sVCAM-1 increased with exercise and during the recovery period, our findings support the concept that SCT athletes might be at risk for microcirculatory disturbances and adhesive phenomena developing at rest and several hours after exercise. Alpha-thalassemia might be considered protective among exercising SCT subjects.




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