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J Appl Physiol (June 1, 2006). doi:10.1152/japplphysiol.00267.2006
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Submitted on March 1, 2006
Accepted on May 19, 2006

Evidence for a role of neuroepithelial bodies as complex airway sensors: comparison with smooth muscle-associated airway receptors

Dirk Adriaensen1*, Inge Brouns1, Isabel Pintelon1, Ian De Proost1, and Jean-Pierre Timmermans1

1 Laboratory of Cell Biology and Histology, Department of Veterinary Medicine, University of Antwerp, Antwerp, Belgium

* To whom correspondence should be addressed. E-mail: dirk.adriaensen{at}ua.ac.be.

The epithelium of intrapulmonary airways in many species harbors diffusely spread innervated groups of neuroendocrine cells, called neuroepithelial bodies (NEBs). Data on the location, morphology and chemical coding of NEBs in mammalian lungs are abundant, but none of the proposed functions has so far been fully established. Besides C-fiber afferents, slowly adapting stretch receptors and rapidly adapting stretch receptors, recent reviews have added NEBs to the list of presumed sensory receptors in intrapulmonary airways. Physiologically the innervation of NEBs, however, remains enigmatic. This short overview summarizes our present understanding of the chemical coding and exact location of the receptor end organs of myelinated vagal airway afferents in intrapulmonary airways. The profuse populations that selectively contact complex pulmonary NEB receptors are compared to the much smaller group of smooth muscle-associated airway receptors (SMARs). The main objective of our contribution was to stimulate the idea that the different populations of myelinated vagal afferents that selectively innervate intraepithelial pulmonary NEBs may represent subpopulations of the extensive group of known electrophysiologically characterized myelinated vagal airway receptors. Future efforts should be directed towards finding out which airway receptor groups are selectively coupled to the complex NEB receptors.




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