Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

J Appl Physiol (May 11, 2006). doi:10.1152/japplphysiol.00259.2006
This Article
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
101/2/566    most recent
00259.2006v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nickerson, M.
Right arrow Articles by Fleshner, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nickerson, M.
Right arrow Articles by Fleshner, M.
Submitted on February 28, 2006
Accepted on May 4, 2006

Sexual dimorphism of the intracellular Heat Shock Protein 72 response

Molly Nickerson1, Sarah L Kennedy1, John D Johnson1, and Monika Fleshner1*

1 Integrative Physiology, University of Colorado, Boulder, Colorado, United States

* To whom correspondence should be addressed. E-mail: monika.fleshner{at}colorado.edu.

ABSTRACT The majority of previous work examining stress responses has been done in males. Recently, it has become clear that the impact of stressor exposure is modulated by sex. One stress response that may be affected by sex is the induction of intracellular Hsp72, which is a stress-responsive molecular chaperone that refolds denatured proteins and promotes cellular survival. The following study compared Hsp72 in males and females and also examined if the estrous cycle altered Hsp72 induction in females. We hypothesized that females compared to males would have a constrained Hsp72 response after an acute stressor and that stress-induced Hsp72 response in females would fluctuate with the estrous cycle. Male and female F344 rats were either left in their home cage or exposed to acute tailshock stress (8-10/group). Immediately following stressor, trunk blood was collected and tissues were flash frozen. Vaginal smear and estrogen EIA were used to categorize the phase of estrous. Results show that female rats had a greater corticosterone response than males, that both males and females exhibit a stress-induced release of progesterone, and that males and females had equal levels of stress-induced circulating norepinephrine. Sexual dimorphism of the Hsp72 (ELISA) response existed in pituitary gland, mesenteric lymph nodes, and liver such that female rats had an attenuated Hsp72 response compared to males after stress. The adrenal glands, spleen, and heart did not exhibit sexual dimorphism of the Hsp72 response. The estrous cycle did not have a significant effect on basal or stress-induced Hsp72 in females.




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
E. Bombardier, C. Vigna, S. Iqbal, P. M. Tiidus, and A. R. Tupling
Effects of ovarian sex hormones and downhill running on fiber-type-specific HSP70 expression in rat soleus
J Appl Physiol, June 1, 2009; 106(6): 2009 - 2015.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
C. Penaloza, B. Estevez, S. Orlanski, M. Sikorska, R. Walker, C. Smith, B. Smith, R. A. Lockshin, and Z. Zakeri
Sex of the cell dictates its response: differential gene expression and sensitivity to cell death inducing stress in male and female cells
FASEB J, June 1, 2009; 23(6): 1869 - 1879.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. L. Orr, S. Huang, M. A. Roberts, J. C. Reed, S. Li, and X.-J. Li
Sex-dependent Effect of BAG1 in Ameliorating Motor Deficits of Huntington Disease Transgenic Mice
J. Biol. Chem., June 6, 2008; 283(23): 16027 - 16036.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. A. Brown, M. S. Johnson, C. J. Armstrong, J. M. Lynch, N. M. Caruso, L. B. Ehlers, M. Fleshner, R. L. Spencer, and R. L. Moore
Short-term treadmill running in the rat: what kind of stressor is it?
J Appl Physiol, December 1, 2007; 103(6): 1979 - 1985.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1948 by the American Physiological Society.