Journal of Applied Physiology Track the topics, authors and articles important to you
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

J Appl Physiol (June 11, 2004). doi:10.1152/japplphysiol.00259.2004
This Article
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
97/4/1437    most recent
00259.2004v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Aviles, H.
Right arrow Articles by Sonnenfeld, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Aviles, H.
Right arrow Articles by Sonnenfeld, G.
Submitted on March 12, 2004
Accepted on June 6, 2004

Active Hexose Correlated Compound Enhances the Immune Function of Mice in the Hindlimb-Unloading Model of Space Flight Conditions

Hernan Aviles1, Tesfaye Belay1, Monique Vance1, Buxiang Sun2, and Gerald Sonnenfeld1*

1 Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, Georgia, USA
2 Amino Up Chemical Company, Sapporo, Japan

* To whom correspondence should be addressed. E-mail: sonneng{at}msm.edu.

Hindlimb-unloading is a ground-based model that simulates some of the aspects of space flight conditions including lack of load bearing on hindlimbs and a fluid shift to the head. It has been shown that treatment with Active Hexose Correlated Compound (AHCC) restores resistance to infection in mice maintained under hindlimb-unloading conditions. The present study was designed to clarify the mechanisms by which AHCC enhances resistance to infection in this model. We hypothesized that oral administration of AHCC will enhance the function of the immune system, which could lead to the increased resistance to infection observed in this model. AHCC or the excipient was orally administered to mice and the function of the immune system was assessed in spleen and peritoneal cells isolated from those groups. The results of the current study showed that, administration of AHCC for one week prior to and throughout the 2nd day of hindlimb-unloading period enhanced the function of the immune system assessed by spleen cell proliferation and cytokine production in spleens and nitric oxide and cytokine production in peritoneal cells. These findings suggest that AHCC can be used as a potent immunoenhancer especially in cases where the immune system is suppressed by any condition including diseases such as HIV infection and cancer.




This article has been cited by other articles:


Home page
 J. Leukoc. Biol.Home page
N. Gueguinou, C. Huin-Schohn, M. Bascove, J.-L. Bueb, E. Tschirhart, C. Legrand-Frossi, and J.-P. Frippiat
Could spaceflight-associated immune system weakening preclude the expansion of human presence beyond Earth's orbit?
J. Leukoc. Biol., November 1, 2009; 86(5): 1027 - 1038.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
A. Daddaoua, E. Martinez-Plata, R. Lopez-Posadas, J. M. Vieites, M. Gonzalez, P. Requena, A. Zarzuelo, M. D. Suarez, F. S. de Medina, and O. Martinez-Augustin
Active Hexose Correlated Compound Acts as a Prebiotic and Is Antiinflammatory in Rats with Hapten-Induced Colitis
J. Nutr., May 1, 2007; 137(5): 1222 - 1228.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
B. W. Ritz, S. Nogusa, E. A. Ackerman, and E. M. Gardner
Supplementation with Active Hexose Correlated Compound Increases the Innate Immune Response of Young Mice to Primary Influenza Infection
J. Nutr., November 1, 2006; 136(11): 2868 - 2873.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. A. Gashev, M. D. Delp, and D. C. Zawieja
Inhibition of active lymph pump by simulated microgravity in rats
Am J Physiol Heart Circ Physiol, June 1, 2006; 290(6): H2295 - H2308.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1966 by the American Physiological Society.