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J Appl Physiol (April 11, 2003). doi:10.1152/japplphysiol.00259.2003
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Submitted on March 12, 2003
Accepted on April 4, 2003

Active Hexose Correlated Compound Enhances Resistance to Klebsiella pneumoniae Infection in Mice in the Hindlimb-Unloading Model of Space Flight Conditions

Hernan Aviles1, Tesfaye Belay1, Kimberly Fountain1, Monique Vance1, Buxiang Sun2, and Gerald Sonnenfeld1*

1 Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA, USA
2 Amino Up Chemical Company, Sapporo, Japan

* To whom correspondence should be addressed. E-mail: sonneng{at}msm.edu.

Previous studies have demonstrated that resistance to infection is decreased in Swiss/Webster female mice maintained in the hindlimb-unloading model. This a model of some of the aspects of space flight conditions including lack of load-bearing on hindlimbs and a fluid shift to the head. Active Hexose Correlated Compound (AHCC), extracted from Basidiomycete mushrooms, has been shown to induce enhancement of immune responses, including enhanced natural killer activity. In the present study, AHCC was orally administered to mice to determine if the treatment could decrease immunosuppression and mortality of mice maintained in the hindlimb unloaded model infected with Klebsiella pneumoniae. The results of the current study showed that administration of AHCC by gavage for one week (1g/kg body weight) prior to suspension and throughout the 10 day suspension period yielded significant beneficial effects for the hindlimb unloaded group including: 1) decreased mortality, 2) increased time to death and, 3) increased ability to clear bacteria. The results suggest that AHCC can decrease the deleterious effects of the hindlimb unloading model on immunity and resistance to infection.




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