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J Appl Physiol (May 10, 2002). doi:10.1152/japplphysiol.00254.2002
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Articles in PresS, published online ahead of print May 10, 2002
J Appl Physiol, 10.1152/jap.00254.2002
Submitted on March 28, 2002
Accepted on May 3, 2002

Major gene effects on exercise ventilatory threshold: the HERITAGE Family Study

Mary F Feitosa1*, Steven E Gaskill2, Treva Rice1, Tuomo Rankinen3, Claude Bouchard3, D.C. Rao4, Jack H Wilmore5, James S Skinner6, and Arthur S Leon7

1 Division of Biostatistics, Washington University School of Medicine, STL, MO, USA
2 Department of Health and Human Performance, University of Montana, Missoula, MT, USA
3 Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA
4 Division of Biostatistics, Washington University School of Medicine, STL, MO, USA; Departments of Genetics and Psychiatry, Washington University School of Medicine, STL, MO, USA
5 Department of Health and Kinesiology, Texas A & M University, College Station, TX, USA
6 Department of Kinesiology, Indiana University, Bloomington, IN, USA
7 School of Kinesiology and Leisure Studies, University of Minnesota, Minneapolis, MN, USA

* To whom correspondence should be addressed. E-mail: maryf{at}wubios.wustl.edu.

This study investigates whether there are major gene effects on oxygen uptake at the ventilatory threshold (VO2vt) and the VO2vt/maximal oxygen uptake (VT%VO2max), at baseline and in response to 20-weeks of exercise training, using data on 336 Whites and 160 Blacks. Segregation analysis was performed on the residuals of VO2vt and VT%VO2max. In Whites, there was strong evidence of a major gene, with 3% and 2% of the sample in the upper distribution, that accounted for 52% and 43% of the variance in baseline VO2vt and VT%VO2max, respectively. There were no genotype-specific-covariate effects (sex, age, weight, fat-mass and fat-free-mass). The segregation results were inconclusive for the training-response in Whites, and for the baseline and training-response in Blacks, probably due to insufficient power because of reduced sample sizes or smaller gene effect or both. The strength of the genetic evidence for VO2vt and VT%VO2max suggests that these traits should be further investigated for potential relations with specific candidate genes, if they can be identified, and explored through a genome-wide scan.




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