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J Appl Physiol (January 7, 2005). doi:10.1152/japplphysiol.00245.2004
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Submitted on March 8, 2004
Accepted on January 4, 2005

3He MRI-based Assessment of Posture-dependent Regional Ventilation Gradients in Rats

Sven Mansson1*, Anselm J. Deninger2, Peter Magnusson2, Goran Pettersson2, Lars E. Olsson2, Georg Hansson2, Per Wollmer3, and Klaes Golman2

1 Department of Experimental Research, Malmo University Hospital, Malmo, Sweden
2 Amersham Health R&D AB, Malmo, Sweden
3 Department of Clinical Physiology, Malmo University Hospital, Malmo, Sweden

* To whom correspondence should be addressed. E-mail: Sven.Mansson{at}rontgen.mas.lu.se.

A recently developed method for quantitative assessment of regional lung ventilation was employed for the study of posture-dependent ventilation differences in rats. The measurement employed hyperpolarized 3He MRI to detect the build-up of the signal intensity after increasing numbers of 3He breaths, which allowed for computation of a regional ventilation parameter. A group of six anaesthetized rats was studied in both supine and prone postures. Three-dimensional maps of the ventilation parameter were obtained with high spatial reso- lution (voxel volume ~2 mm3). Vertical (dorsal-ventral) gradients of the ventilation index, defined as the regional ventilation normalized by the average ventilation within the whole lung, were investigated. Variations in the regional distribution of the ventilation parameter, as well as of the ventilation index, could be detected depending on the posture of the rats. In supine posture, ventilation was elevated in the dependent parts of the lungs, with a linear gradient of the ventilation index of -0.11 ± 0.03 cm-1. In prone posture, the distribution of ventilation was more uniform, with a significantly (p < 0.001) smaller gradient of the venti-lation index of -0.01 ± 0.02 cm-1. It is concluded that the 3He MRI-based method can detect and quantify regional ventilation gradients in animals as small as the rat, and that these gradients depend on prone or supine posture of the animal.




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