Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

J Appl Physiol (September 22, 2005). doi:10.1152/japplphysiol.00240.2005
This Article
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
100/1/26    most recent
00240.2005v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Harmer, A. R.
Right arrow Articles by Flack, J. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Harmer, A. R.
Right arrow Articles by Flack, J. R.
Submitted on March 1, 2005
Accepted on September 20, 2005

Effects of sprint training on extrarenal potassium regulation with intense exercise in type 1 diabetes

Alison R. Harmer1*, Patricia A. Ruell2, Michael J. McKenna3, Donald J. Chisholm4, Sandra K. Hunter2, Jeanette M. Thom2, Norman R. Morris2, and Jeff R. Flack5

1 School of Exercise and Sport Science, The University of Sydney, Lidcombe, NSW, Australia; School of Physiotherapy, The University of Sydney, Lidcombe, NSW, Australia
2 School of Exercise and Sport Science, The University of Sydney, Lidcombe, NSW, Australia
3 School of Human Movement, Recreation, and Performance, Centre for Aging Rehabilitation, Exercise and Sport, Victoria University of Technology, Melbourne, VIC, Australia
4 Diabetes and Metabolism, The Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
5 Diabetes Centre, Bankstown-Lidcombe Hospital, Bankstown, NSW, Australia

* To whom correspondence should be addressed. E-mail: A.Harmer{at}fhs.usyd.edu.au.

Effects of sprint training on plasma [K+] regulation during intense exercise and on muscle Na+K+ATPase were investigated in subjects with type 1 diabetes mellitus (T1D) under real life conditions and non-diabetics (CON). Eight subjects with T1D and 7 CON undertook 7 weeks of sprint cycling training. Before training, subjects cycled to exhaustion at 130% VO2peak. After training identical work was performed. Arterialised venous blood was drawn at rest, and in exercise and recovery and analysed for plasma glucose, [K+], [Na+], catecholamines, insulin, and glucagon. A vastus lateralis biopsy was obtained before and after training and assayed for Na+K+ATPase content ([3H]ouabain binding). Pre-training, Na+K+ATPase content and the rise in plasma [K+] ({Delta}[K+]) during maximal exercise were similar in T1D and CON. However, after 60 min recovery in T1D, plasma [K+], glucose, and glucagon/insulin were higher, and plasma [Na+] was lower than in CON. Training increased Na+K+ATPase content and reduced {Delta}[K+] in both groups (P<0.05). These variables were correlated in CON (r = -0.65, P<0.05), but not T1D. This study showed firstly that mildly hypoinsulinemic subjects with T1D can safely undertake intense exercise with respect to K+ regulation, however, elevated [K+] will ensue in recovery unless insulin is administered. Secondly, sprint training improved K+ regulation during intense exercise in both T1D and CON groups, however, the lack of correlation between plasma {Delta}[K+] and Na+K+ATPase content in T1D may indicate different relative contributions of K+-regulatory mechanisms.




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
R. J. Aughey, K. T. Murphy, S. A. Clark, A. P. Garnham, R. J. Snow, D. Cameron-Smith, J. A. Hawley, and M. J. McKenna
Muscle Na+-K+-ATPase activity and isoform adaptations to intense interval exercise and training in well-trained athletes
J Appl Physiol, July 1, 2007; 103(1): 39 - 47.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
A. R. Harmer, D. J. Chisholm, M. J. McKenna, N. R. Morris, J. M. Thom, G. Bennett, and J. R. Flack
High-Intensity Training Improves Plasma Glucose and Acid-Base Regulation During Intermittent Maximal Exercise in Type 1 Diabetes
Diabetes Care, May 1, 2007; 30(5): 1269 - 1271.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1948 by the American Physiological Society.