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Articles in PresS, published online ahead of print August 2, 2002
J Appl Physiol, 10.1152/jap.00229.2002
Submitted on March 18, 2002
Accepted on July 19, 2002
1 Department of Exercise and Movement Science, University of Oregon, Eugene, OR, USA
2 Department of Kinesiology and Physiology Program, The Pennsylvania State University, University Park, PA, USA
* To whom correspondence should be addressed. E-mail: minson{at}oregon.uoregon.edu.
Cutaneous vasodilation is reduced in healthy older versus young subjects; however, the mechanisms that underlie these age-related changes are unclear. Our goal in the present study was to determine the role of NO and the axon reflexes in the skin blood flow (SkBF) response to local heating with advanced age. We placed two microdialysis fibers in the forearm skin of 10 young (Y; 22±2 years) and 10 older (O; 77±5 years) men and women. SkBF over each site was measured by laser-Doppler flowmetry (LDF; Moor DRT4). Both sites were heated to 42°C for ~60 minutes while 10mM L-NAME was infused throughout the protocol to inhibit NO-synthase (NOS) in one site, and 10mM L-NAME was infused after 40 minutes of local heating in the second site. Data were expressed as a percent of maximal vasodilation (28mM nitroprusside infusion). Local heating prior to L-NAME infusion resulted in a significantly reduced initial peak (Y:61±2%max vs. O:46±4%max) and plateau (Y:93±2%max vs. O:82±5%max) CVC values in older subjects (P<0.05). When NOS was inhibited after 40 minutes of heating, CVC declined to the same value in the young and older groups. Thus, the overall contribution of NO to the plateau phase of the SkBF response to local heating was less in the older subjects. The initial peak response was significantly lower in the older subjects in both microdialysis sites (Y:52±4%max vs. O:38±5%max; P<0.05). These data suggest that age-related changes in both axon reflex-mediated and NO-mediated vasodilation contribute to attenuated cutaneous vasodilator responses in the elderly.
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