Capillary circulation is delicately regulated by microvascular constriction mechanisms, thereby controlling capillary perfusion and transmural pressure. The influence of posture on capillary flow has been investigated both in diseased and healthy people. However, its influence on capillary pressure has rarely been investigated. We measured capillary pressures in the supine and sitting positions in the hallux of healthy volunteers. The capillaries in the eponychium of the hallux were punctured using a micropipette connected to a micropressure system (900A, WPI). Also, non-invasive peripheral arterial and invasive venous pressures were measured in both positions. The rise in systolic capillary pressure from supine to sitting position (32 mm Hg; from 39 to 71 mm Hg, resp.) was significantly (p<.001) smaller than the rise in systolic arterial toe pressure (57 mm Hg; from 87 to 144 mm Hg, resp.) and venous pressure (41 mm Hg, from 26 mm Hg to 67 mm Hg, resp.). This study shows that the postural rise in precapillary arteriolar pressure is not completely transmitted to the capillaries, probably due to activation of peripheral vasoconstiction mechanisms.