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J Appl Physiol (August 2, 2002). doi:10.1152/japplphysiol.00210.2002
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Articles in PresS, published online ahead of print August 2, 2002
J Appl Physiol, 10.1152/jap.00210.2002
Submitted on March 12, 2002
Accepted on July 31, 2002

Detection of Inspiratory Resistive Loads in Double Lung Transplant Recipients

Weiying Zhao1, A. Daniel Martin1, and Paul W Davenport2*

1 Department of Physical Threapy, University of Florida, Gainesville, Florida, USA
2 Department of Physiological Sciences, University of Florida, Gainesville, Florida, USA

* To whom correspondence should be addressed. E-mail: DAVENPORTP{at}MAIL.VETMED.UFL.EDU.

The afferent pathways mediating respiratory load perception are still largely unknown. In order to assess the role of lung vagal afferents in respiratory sensation, detection of inspiratory resistive loads was compared between 10 double lung transplant recipients (DLT) with normal lung function and that in 12 health control subjects (NOR). Despite a similar unloaded and loaded breathing pattern, the DLT group had a significantly higher detection threshold (2.91 ± 0.5 cmH2O/L/s vs 1.55 ± 0.3 cmH2O/L/s) and Weber Fraction (0.50 ± 0.1 vs 0.30 ± 0.1), as compared with the NOR group. These results suggest that inspiratory resistive load detection occurs in the absence of vagal afferent feedback from the lung, but lung vagal afferents contribute to inspiratory resistive load detection response in humans. Lung vagal afferents are not essential to the regulation of resting breathing and load compensation responses.




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