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Articles in PresS, published online ahead of print June 21, 2002
J Appl Physiol, 10.1152/jap.00209.2002
Submitted on March 12, 2002
Accepted on June 20, 2002
1 Dipartimento di Medicina Interna, Universita di Genova, Genoa, Italy
2 Fisiopatologia Respiratoria, Azienda Ospedaliera S. Croce e Carle, Genoa, Italy
* To whom correspondence should be addressed. E-mail: brusasco{at}dism.unige.it.
Deep breaths taken before inhalation of methacholine attenuate the decrease in 1-s forced expiratory volume (FEV1) and forced vital capacity (FVC) in healthy but not in asthmatic subjects. We investigated whether this difference also exists using measurements not preceded by full inflation, such i.e. airway conductance, functional residual capacity, as well as flow and residual volume from partial forced expiration. We found that 5 deep breaths preceding a single dose of methacholine 1) transiently attenuated the decrements in FEV1 and FVC in healthy (n=8), but not in mild asthmatic (n=10) subjects, and 2) increased the areas under the curve of changes in parameters not preceded by a full inflation over 40 min during which further deep breaths were prohibited, without significant difference between healthy (n=6) and asthmatic (n=16) subjects. In conclusion, a series of deep breaths preceding methacholine inhalation significantly enhance bronchoconstrictor response, similarly in asthmatic and healthy subjects but facilitates bronchodilatation upon further inflation in the latter.
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