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1 Graduate School of Human Sciences, Waseda University, Tokorozawa, Saitama, Japan; Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi, Tokyo, Japan
2 Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi, Tokyo, Japan
3 Graduate School of Human Sciences, Waseda University, Tokorozawa, Saitama, Japan
4 School of Sports Sciences, Waseda University, Tokorozawa, Saitama, Japan
* To whom correspondence should be addressed. E-mail: mizuno{at}toki.waseda.jp.
The purposes of this investigation were to evaluate regional differences in blood flow and oxygen consumption and their relationship in exercised muscle during recovery from exhaustive exercise. Five healthy male subjects performed an exhaustive one-legged cycling exercise. Blood flow, oxygen uptake, and oxygen extraction were measured in the quadriceps femoris muscle before and after exercise using positron emission tomography. Regions of interest included five areas of the muscle-two proximal, one central, and two distal-which were evenly spaced across the muscle. Before exercise, blood flow and oxygen consumption decreased significantly (P < 0.05) in the direction from the proximal to the distal portions; blood flow declined from 2.0 ± 0.5 to 1.4 ± 0.3 ml.100g-1.min-1, and oxygen consumption decreased from 0.21 ± 0.04 to 0.17 ± 0.02 ml.100g-1.min-1. In contrast, these gradients in blood flow and oxygen consumption diminished during recovery after exercise. Consequently, there was a positive relationship between changes in blood flow and oxygen consumption in an exercised muscle during recovery after exercise (r = 0.963, P < 0.01). These changes became larger in the direction from proximal to distal portions; blood flow increased from 2.9 ± 0.7 to 3.9 ± 0.8, and oxygen consumption: from 1.4 ± 0.1 to 1.8 ± 0.4 times resting values. These results suggest that hemodynamic variables are heterogeneous within a muscle both at rest and during recovery from exercise, and that there is a systematic difference in these variables in the direction from proximal to distal regions within the quadriceps femoris muscle.
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