| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Department of Medicine, Division of Endocrinology, Metabolism and Diabetes, University of Colorado Health Sciences Center, Denver, CO, USA
2 Department of Pediatrics, Section of Nutrition, University of Colorado Health Sciences Center, Denver, CO, USA
* To whom correspondence should be addressed. E-mail: leigh.perreault{at}uchsc.edu.
Effects of a single exercise bout on insulin action were compared in men (n=10) and women (n=10). On an exercise day, subjects cycled for 90 minutes at 85% lactate threshold, whereas on a rest (control) day, they remained semi-recumbent. The period of exercise, or rest, was followed by a 3-hour hyperinsulinemic/euglycemic clamp (30mU/m2/min) and indirect calorimetry. Glucose kinetics were measured isotopically using an infusion of [6,6-2H2] glucose. Glucose infusion rate (GIR) during the clamp on the rest day was not different between the genders. However, GIR on the exercise day was significantly lower in men compared to women (p=0.01). This was mainly due to a significantly lower glucose rate of disappearance (Rd) in men compared to women (p=0.05), whereas no differences were observed in the endogenous glucose rate of appearance (Ra). Non-protein respiratory quotient (NPRQ) increased significantly during the clamp from pre-clamp measurements in men and women on the rest day (p<0.01). Exercise abolished the increase in NPRQ seen during the clamp on the rest day, and tended to decrease NPRQ in men. Our results indicate: 1) Exercise abolishes the usual increase in NPRQ observed during a hyperinsulinemic/euglycemic clamp in both genders, 2) Men exhibit relatively lower whole-body insulin action in the 3-4h following exercise compared to women, 3) Gender differences in insulin action may be explained by a lower Rd in the men after acute exercise. Together, these data imply gender differences in insulin action post-exercise exist in peripheral tissues, and not in liver.
This article has been cited by other articles:
|
|
 |
|
  L. Perreault, B. C. Bergman, M. C. Playdon, C. Dalla Man, C. Cobelli, and R. H. Eckel Impaired fasting glucose with or without impaired glucose tolerance: progressive or parallel states of prediabetes? Am J Physiol Endocrinol Metab, August 1, 2008; 295(2): E428 - E435. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Roepstorff, M. Donsmark, M. Thiele, B. Vistisen, G. Stewart, K. Vissing, P. Schjerling, D. G. Hardie, H. Galbo, and B. Kiens Sex differences in hormone-sensitive lipase expression, activity, and phosphorylation in skeletal muscle at rest and during exercise Am J Physiol Endocrinol Metab, November 1, 2006; 291(5): E1106 - E1114. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Roepstorff, M. Thiele, T. Hillig, H. Pilegaard, E. A. Richter, J. F. P. Wojtaszewski, and B. Kiens Higher skeletal muscle {alpha}2AMPK activation and lower energy charge and fat oxidation in men than in women during submaximal exercise J. Physiol., July 1, 2006; 574(1): 125 - 138. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Englert, K. Wells, W. Long, M. S. Hickey, and C. L. Melby Effect of Acute Prior Exercise on Glycemic and Insulinemic Indices J. Am. Coll. Nutr., June 1, 2006; 25(3): 195 - 202. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
